Bioactive gentixanthone and gentichromone from the whole plants of Gentianella acuta (Michx.) Hulten
| Autor: | Haiyang Yu, Lu Qu, Jingya Ruan, Yanxia Liu, Yi Zhang, Lifeng Han, Yajuan Ni, Tao Wang |
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| Rok vydání: | 2016 |
| Předmět: |
Pharmacology
Molecular Structure 010405 organic chemistry Xanthones Gentianella acuta General Medicine In Vitro Techniques Biology biology.organism_classification 01 natural sciences 0104 chemical sciences Intestines Mice Structure-Activity Relationship 010404 medicinal & biomolecular chemistry chemistry.chemical_compound Gentianella chemistry Drug Discovery Xanthone Botany Animals Peristalsis |
| Zdroj: | Fitoterapia. 113:164-169 |
| ISSN: | 0367-326X |
| Popis: | Five new compounds, gentixanthones A 1 ( 1 ), A 2 ( 2 ), and gentichromones A 1 –A 3 ( 3 – 5 ), together with thirteen known xanthones ( 6 – 18 ) were obtained from the whole plants of Gentianella acuta (Michx.) Hulten. Their structures were elucidated by chemical and spectroscopic methods. Among them, compounds 6 , 8 , 13 , 14 , and 17 were obtained from Gentianella genus firstly, and 7 , 12 , 15 , 16 , and 18 were isolated from this plant for the first time. Meanwhile, inhibitory effects of 1 – 18 on motility of mouse isolated intestine tissue were determined. As results, xanthones 1 , 2 , 6 , 7 , 9 , 10 and 14 were found to have significant reduce effect on intestine contraction tension, and structure-activity relationship was discussed. |
| Databáze: | OpenAIRE |
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