Antifungal activity of some Tanzanian plants used traditionally for the treatment of fungal infections
| Autor: | Haji O. Selemani, Mainen J. Moshi, Paul E. Verweij, Zakaria H. Mbwambo, Carolien J. P. Van Den Bout‐van den Beukel, Frans Mikx, André J. A. M. van der Ven, Omar J M Hamza, Mecky Matee |
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| Rok vydání: | 2006 |
| Předmět: |
Antifungal Agents
Infectious diseases and international health [NCEBP 13] Clausena anisata Microbial Sensitivity Tests Candida parapsilosis Tanzania Microbiology Invasive mycoses and compromised host [N4i 2] Candida tropicalis Candida krusei Effective Primary Care and Public Health [EBP 3] Drug Discovery Candida albicans Medicine African Traditional Pharmacology Cryptococcus neoformans Plants Medicinal biology Candida glabrata Broth microdilution Fungi Poverty-related infectious diseases [N4i 3] biology.organism_classification Pathogenesis and modulation of inflammation [N4i 1] Ethnopharmacology Plant Preparations Microbial pathogenesis and host defense [UMCN 4.1] Infection and autoimmunity [NCMLS 1] Immunity infection and tissue repair [NCMLS 1] |
| Zdroj: | Journal of Ethnopharmacology, 108, 124-32 Journal of Ethnopharmacology, 108, 1, pp. 124-32 |
| ISSN: | 0378-8741 |
| DOI: | 10.1016/j.jep.2006.04.026 |
| Popis: | Contains fulltext : 50678.pdf (Publisher’s version ) (Closed access) Using the ethnobotanical approach, some Tanzanian plants reported to be used by traditional healers for the treatment of oral candidiasis and fungal infections of the skin were collected and screened for their antifungal activity against Candida albicans, Candida glabrata, Candida tropicalis, Candida parapsilosis, Candida krusei and Cryptococcus neoformans. A total of 65 crude methanol extracts belonging to 56 plant species and 38 families were screened using the broth microdilution method, according to the guidelines of the Clinical and Laboratory Standard Institute (CLSI) (formerly, National Committee for Clinical and Laboratory Standards) [National Committee for Clinical Laboratory Standards, 2002. Reference Method for Broth Dilution Antifungal Susceptibility Testing of Yeasts. Approved Standard-2nd Edition M27-A2, National Committee for Clinical Laboratory Standards, Wayne, PA, USA]. Among the tested plant species, 45% (25 species) showed antifungal activity against one or more of the test fungi. The most susceptible yeasts were Cryptococcus neoformans, followed by Candida krusei, Candida tropicalis, and Candida parapsilosis. The least susceptible were Candida albicans and Candida glabrata. Strong antifungal activity was exhibited by extracts of Clausena anisata Oliv., Sclerocariya birrea Sond, Turraea holstii Gurk, Sterculia africana (Lour) Fiori, Acacia robusta subsp. Usambarensis (Taub) Brenan, Cyphosterma hildebrandti (Gilg), Desc, Elaeodendron buchannanii (Lows), Acacia nilotica (L.) Wild ex Del, Jatropha multifida L., and Pteridium aquilinum (L.) Kuhn. |
| Databáze: | OpenAIRE |
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