A Systematic Review of Risk Factors for Brain Metastases and Value of Prophylactic Cranial Irradiation in Non-Small Cell Lung Cancer
| Autor: | Xiaomei Li, Lan Ye, Cuihong Wang, Yuhua Jiang, Huaying Hou, D.L. Sun, Likuan Hu, Ying Cai |
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| Rok vydání: | 2014 |
| Předmět: |
Oncology
Cancer Research medicine.medical_specialty Funnel plot Lung Neoplasms Epidemiology Risk Factors Carcinoma Non-Small-Cell Lung Internal medicine Carcinoma Humans Medicine Lung cancer Brain Neoplasms business.industry Public Health Environmental and Occupational Health Odds ratio Publication bias medicine.disease Surgery Meta-analysis Conventional PCI Carcinoma Squamous Cell Cranial Irradiation Prophylactic cranial irradiation business |
| Zdroj: | Asian Pacific Journal of Cancer Prevention. 15:1233-1239 |
| ISSN: | 1513-7368 |
| DOI: | 10.7314/apjcp.2014.15.3.1233 |
| Popis: | Background The incidence of brain metastases (BM) varies in patients with non-small cell lung cancer (NSCLC), calls into question the value of prophylactic cranial irradiation (PCI). It is possible that clinicopathologic characteristics are associated with the development of BM, but these have yet to be identified in detail. Thus, we conducted the present meta-analysis on risk factors for BM and the value of PCI in patients with NSCLC. Methods Eligible data were extracted and the risk factors for BM and the value of PCI in patients with NSCLC were analyzed by calculating the pooled odds ratio (OR). Heterogeneity was detected using Q and I-squared statistics, and publication bias was tested by funnel plots and Egger's test. Results Six randomized controlled trials with a focus on the value of PCI and 13 eligible studies with a focus on risk factors for BM were included. PCI significantly reduced the incidence of BM in patients with NSCLC (p=0.000, pooled OR=0.34, 95% confidence interval = 0.37-0.59). Compared with non-squamous cell carcinoma, squamous cell carcinoma was associated with a low incidence of BM in patients with NSCLC (p=0.000, pooled OR=0.47, 95% confidence interval =0.34- 0.65). The funnel plot and Egger's test suggested that there was no publication bias in the current meta-analysis. Conclusions This meta-analysis provides statistical evidence that compared with non-squamous cell carcinoma, squamous cell carcinoma can be used as a predictor for BM in patients with NSCLC, and PCI might reduce the incidence of BM in patients with NSCLC, but does not provide a survival benefit. |
| Databáze: | OpenAIRE |
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