Cumulative exposure to estrogen and psychosis: a peak bone mass, case-control study in first-episode psychosis
| Autor: | Jim van Os, Vera Popovic, Nada Pilipovic, Nadja P. Maric, Miroslava Jašović-Gašić |
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| Rok vydání: | 2005 |
| Předmět: |
Adult
Peak bone mass medicine.medical_specialty Psychosis Time Factors medicine.drug_class medicine.medical_treatment Cumulative Exposure Absorptiometry Photon Sex Factors Bone Density Internal medicine medicine Humans Antipsychotic Biological Psychiatry Bone mineral First episode Lumbosacral Region Estrogens medicine.disease Psychiatry and Mental health Endocrinology Psychotic Disorders Estrogen Schizophrenia Case-Control Studies Female Bone Diseases Psychology Antipsychotic Agents |
| Zdroj: | Schizophrenia Research. 73:351-355 |
| ISSN: | 0920-9964 |
| DOI: | 10.1016/j.schres.2004.07.016 |
| Popis: | The organizational structural effects of estrogen may be cumulative and permanent by impacting on neurodevelopment, giving rise to “neuroprotective” effects and eventually reduction of psychosis risk. Reduction in bone mineral density (BMD, in g/cm 2 ), as a biological marker of reduced cumulative exposure to estrogen, may be a marker of increased psychosis risk. A sample of 19 first-episode female psychosis patients with minimal previous antipsychotic exposure (mean 10 weeks) and 20 female controls underwent advanced fan-beam dual X-ray absorptiometry (DXA) to assess lumbal spine BMD of the region of L1–L4. Mean BMD was around one standard deviation lower in patients (1.13, S.D.=0.10) than in controls (1.25, S.D.=0.12; p =0.0021), and 84% of patients scored below the median value of the controls (OR=5.3, 95% CI: 1.2, 24.2). The results are compatible with the hypothesis that psychosis in women may be associated causally with a reduced protective effect of estrogen over the course of development. |
| Databáze: | OpenAIRE |
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