Inverse association of certain seminal phthalate metabolites with semen quality may be mediated by androgen synthesis: A cross-sectional study from the South China
| Autor: | Yu Liu, Guihua Liu, Yuxing Zeng, Lan Wei, Gang Hu, Jinquan Cheng, Guanxiang Yuan, Peiyi Liu |
|---|---|
| Rok vydání: | 2021 |
| Předmět: |
Adult
Male China Adolescent 010504 meteorology & atmospheric sciences Phthalic Acids Motility Semen Androgen synthesis 010501 environmental sciences 01 natural sciences Phthalate metabolite Andrology Young Adult Semen quality chemistry.chemical_compound medicine Humans Reproductive system Androstenedione lcsh:Environmental sciences Sperm motility 0105 earth and related environmental sciences General Environmental Science lcsh:GE1-350 business.industry Phthalate Environmental Exposure Middle Aged Mono butyl phthalate Spermatozoa Semen Analysis Cross-Sectional Studies chemistry Androgens Sperm Motility Pregnenolone business medicine.drug |
| Zdroj: | Environment International, Vol 151, Iss, Pp 106459-(2021) |
| ISSN: | 0160-4120 |
| Popis: | Background: Several in vitro and in vivo studies have demonstrated the effects of phthalates on androgen synthesis, and the adverse outcomes of phthalate exposure on male reproductive function have been reported. However, the direct relationship among these three factors remains unknown. Objective: To explore the potential roles of steroids involved in androgen synthesis in the association between phthalate exposure and semen quality. Methods: Eighteen phthalate metabolites (mPAEs) and nine steroids were analyzed in semen samples of 403 male participants aged 18–54 years from a hospital in Shenzhen, China. The associations across phthalate metabolites, steroids, and eleven semen quality parameters were evaluated by multivariate linear regression and logistical regression models. The potential contributions of steroids to the associations between phthalate metabolites and semen quality outcomes were explored by mediation effect analysis. Results: In this cross-sectional study, mono-n-butyl phthalate (MnBP) was inversely associated with nine continuous semen quality parameters in a dose-dependent manner (all p for trend |
| Databáze: | OpenAIRE |
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