Antibodies to Mycoplasma in Sera of Leukemic Patients
| Autor: | William H. Murphy, Cora Bullis, Chris J. D. Zarafonetis, Inta J. Ertel |
|---|---|
| Rok vydání: | 1967 |
| Předmět: |
viruses
medicine.medical_treatment Guinea Pigs medicine.disease_cause Antiviral Agents General Biochemistry Genetics and Molecular Biology Neutralization Serology Mycoplasma Cytopathogenic Effect Viral Bone Marrow Neutralization Tests medicine Animals Humans Cytopathic effect Chemotherapy Leukemia biology Complement System Proteins medicine.disease Virology medicine.anatomical_structure Antibody Formation Viruses Immunology biology.protein Rabbits Bone marrow Antibody |
| Zdroj: | Experimental Biology and Medicine. 124:366-372 |
| ISSN: | 1535-3699 1535-3702 |
| DOI: | 10.3181/00379727-124-31744 |
| Popis: | SummaryStudies were done to test whether virus neutralization technics were useful for detecting antibodies in patients' sera that prevented the growth and cytopathic effect (CPE) of mycoplasma isolated from bone marrow specimens of leukemic and non-leukemic patients. A standard virus neutralization technic was satisfactory for special laboratory studies but unsatisfactory for large-scale serologic surveys. Sera from leukemic and nonleukemic patients prevented mycoplasma CPE and growth. Evidence was presented that the CPE neutralizing serum component was complement-dependent, appears to have a seasonal occurrence, and may be a “normal serum antibody.” Sera from children and adults with leukemia about twice as frequently neutralized mycoplasma CPE as sera from normal controls. No correlative pattern was observed between clinical stage of leukemia, chemotherapy, and occurrence of “antibodies” to the test mycoplasma. The problem of interpreting such results was discussed. |
| Databáze: | OpenAIRE |
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