Four new sesquiterpenoids from fruiting bodies of the fungus Inonotus rickii
| Autor: | Ji-Kai Liu, Tao Feng, Wen-Bin Dong, He-Ping Chen, Ze-Jun Dong, Zheng-Hui Li, Yan Li, Xia Yin |
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| Rok vydání: | 2014 |
| Předmět: |
China
Pharmaceutical Science Antineoplastic Agents Fungus Analytical Chemistry Inhibitory Concentration 50 Drug Discovery Botany Humans Fruiting Bodies Fungal Inonotus rickii Nuclear Magnetic Resonance Biomolecular Polycyclic Sesquiterpenes Pharmacology Mushroom Molecular Structure biology Chemistry Organic Chemistry General Medicine Inonotic acid B biology.organism_classification Human colon cancer Complementary and alternative medicine Molecular Medicine Drug Screening Assays Antitumor Agaricales Sesquiterpenes |
| Zdroj: | Journal of Asian Natural Products Research. 16:581-586 |
| ISSN: | 1477-2213 1028-6020 |
| DOI: | 10.1080/10286020.2014.925451 |
| Popis: | Three new bisabolane sesquiterpenoids, inonotic acid A (1), 3-O-formyl inonotic acid A (2), inonotic acid B (3), and one new drimane sesquiterpenoid 3α,6β-dihydroxycinnamolide (4), were isolated from the fruiting bodies of mushroom Inonotus rickii. Their structures were elucidated by means of extensive spectroscopic methods. Compound 4 had moderate inhibitory activity on human colon cancer SW480 (IC50 = 20.4 μmol). |
| Databáze: | OpenAIRE |
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