A Low Ankle Brachial Index is Associated with an Increased Risk of Cardiovascular Disease: The Hisayama Study
| Autor: | Yoichiro Hirakawa, Takanari Kitazono, Naoko Mukai, Toshiharu Ninomiya, Iwao Kojima, Daigo Yoshida, Yutaka Kiyohara, Masayo Fukuhara, Jun Hata |
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| Rok vydání: | 2014 |
| Předmět: |
Male
medicine.medical_specialty Japan Risk Factors Diabetes mellitus Internal medicine Epidemiology Internal Medicine medicine Humans Ankle Brachial Index Prospective Studies Risk factor Prospective cohort study Framingham Risk Score Proportional hazards model business.industry Incidence Biochemistry (medical) Confounding Middle Aged Prognosis medicine.disease Survival Rate body regions Blood pressure Cardiovascular Diseases Physical therapy Female Cardiology and Cardiovascular Medicine business Follow-Up Studies |
| Zdroj: | Journal of Atherosclerosis and Thrombosis. 21:966-973 |
| ISSN: | 1880-3873 1340-3478 |
| Popis: | Aim: Peripheral artery disease (PAD), defined as a decreased ankle brachial index (ABI), is a risk factor for cardiovascular disease; however, few studies have assessed the relationship between a low ABI and cardiovascular risks in Asian populations. We herein examined the relationship between the ABI and the development of cardiovascular disease in a Japanese community. Methods: A total of 2,954community-dwelling Japanese individuals without prior cardiovascular disease ≥ 40years of age were followed up for an average of 7.1years. The subjects’ ABIs were categorized into the three groups: low (≤0.90), borderline (0.91-0.99) and normal (1.00-1.40). We estimated the relationship between the ABI and cardiovascular risk using a Cox proportional hazards model. Results: During the follow-up period, 134subjects experienced cardiovascular events. The incidence of cardiovascular disease across the ABI values was significantly different (p＜0.001). After adjusting for confounding factors, namely age, sex, systolic blood pressure, use of anti-hypertensive drugs, diabetes, total cholesterol, high-density lipoprotein cholesterol, obesity, smoking, alcohol intake and regular exercise, individuals with a low ABI were at 2.40-fold (95% confidence interval [CI] 1.14-5.06) greater risk of cardiovascular disease and 4.13-fold (95% CI 1.62-10.55) greater risk of coronary heart disease. Conclusions: Our findings suggest that individuals with an ABI of ≤ 0.90 have an increased risk of cardiovascular events, independent from traditional risk factors, in the general Japanese population. |
| Databáze: | OpenAIRE |
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