Therapeutic effects of nandrolone and testosterone in adult male HIV patients with AIDS wasting syndrome (AWS): a randomized, double-blind, placebo-controlled trial
| Autor: | Sabyasachi Roy, Deeptarka Roy, Uddalak Majumdar, Amit Kumar Banerjee, Ramtanu Banerjee, Ayan Jha, Partha Sardar, Pradipta Guha, Dipanjan Bandyopadhyay |
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| Rok vydání: | 2010 |
| Předmět: |
Adult
Male medicine.medical_specialty Placebo-controlled study HIV Infections HIV Wasting Syndrome Placebo Weight Gain Injections Intramuscular law.invention Body Mass Index Randomized controlled trial Double-Blind Method law Internal medicine medicine Humans Nandrolone Pharmacology (medical) Testosterone business.industry Therapeutic effect HIV Testosterone (patch) Luteinizing Hormone Skinfold Thickness Infectious Diseases Endocrinology Nandrolone Decanoate Body Composition Quality of Life medicine.symptom Follicle Stimulating Hormone Waist Circumference business Weight gain medicine.drug |
| Zdroj: | HIV clinical trials. 11(4) |
| ISSN: | 1528-4336 |
| Popis: | We aimed to compare therapeutic effects of intramuscular (IM) nandrolone decanoate and IM testosterone enanthate in male HIV patients with AIDS wasting syndrome (AWS) with placebo control.In this randomized, double-blind, placebo-controlled, 12-week trial, 104 patients with AWS who satisfied our inclusion criteria were randomly allotted in a 2:2:1 ratio to the 3 intervention groups: nandrolone, testosterone, and placebo. We administered 150 mg nandrolone and 250 mg testosterone (both IM, biweekly). The primary outcome measure was a comparison of absolute change in weight at 12 weeks between the nandrolone decanoate, testosterone, and placebo groups.Intent-to-treat analysis was done. The nandrolone group recorded maximum mean increase in weight (3.20 kg; post hoc P.01 compared to placebo). Body mass index (BMI) of subjects in the nandrolone group had a significantly greater increase (mean = 1.28) compared to both testosterone (post hoc P.05) and placebo (post hoc P.01). Waist circumference and triceps skinfold thickness of patients on nandrolone showed similar results. Nandrolone also ensured a better quality of life. Patients with low testosterone level (3 ng/mL) benefited immensely from nandrolone therapy, which increased their weight and BMI significantly compared to placebo (P.05).Our trial demonstrates the superior therapeutic effects of nandrolone in male AWS patients, including the androgen deficient. |
| Databáze: | OpenAIRE |
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