The leptin receptor mediates apparent autocrine regulation of leptin gene expression
| Autor: | Rudolph L. Leibel, Ingrid Schmidt, Barbara Nuesslein-Hildesheim, Yiying Zhang, Knut Schwarzer, Margery Nicolson, Ellen Murphy, Martin Olbort, Timothy J. Kowalski |
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| Rok vydání: | 1997 |
| Předmět: |
Leptin
medicine.medical_specialty Genotype Biophysics Adipose tissue Adipokine Receptors Cell Surface medicine.disease_cause Biochemistry Internal medicine Rats Inbred BN Gene expression medicine Animals Autocrine signalling Molecular Biology Gene Mutation Analysis of Variance Leptin receptor Chemistry digestive oral and skin physiology Body Weight Proteins Cell Biology Rats Rats Zucker Endocrinology Adipose Tissue Gene Expression Regulation Protein Biosynthesis Receptors Leptin Regression Analysis Carrier Proteins hormones hormone substitutes and hormone antagonists |
| Zdroj: | Biochemical and biophysical research communications. 240(2) |
| ISSN: | 0006-291X |
| Popis: | The possibility that the leptin receptor (LEPR) mediates autocrine regulation of leptin expression in adipose tissue was examined in 10-day-old Zucker rat pups with different copy numbers of the leptin receptor mutation (Leprfa). Plasma leptin concentrations and adipose tissue mRNA levels for leptin were related to copy number of the mutation (fa/fa>fa/+ > +/+). These relationships were independent of plasma insulin concentration. Reduced copy number for the functional leptin receptor apparently results in a diminished negative feedback signal to the leptin gene in adipose tissue. Thus, leptin appears to close a short regulatory loop controlling its own synthesis in adipose tissue. |
| Databáze: | OpenAIRE |
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