Minimally-Invasive Neural Interface for Distributed Wireless Electrocorticogram Recording Systems

Autor: Euisik Yoon, Chang Sun-Il, Sung-Yun Park
Rok vydání: 2018
Předmět:
Primates
Electrocorticogram (ECoG)
low-power
Preamplifier
Computer science
Interface (computing)
02 engineering and technology
Integrated circuit
intra-skin communication (ISCOM)
low-noise
neural recording
push-pull double-gated amplifier
neural interface
lcsh:Chemical technology
Biochemistry
Noise (electronics)
Article
Analytical Chemistry
law.invention
03 medical and health sciences
0302 clinical medicine
law
Hardware_INTEGRATEDCIRCUITS
0202 electrical engineering
electronic engineering
information engineering
Animals
Wireless
lcsh:TP1-1185
Electrical and Electronic Engineering
Instrumentation
business.industry
020208 electrical & electronic engineering
Brain
Successive approximation ADC
Equipment Design
Multielectrode array
Atomic and Molecular Physics
and Optics
Effective number of bits
CMOS
business
Wireless Technology
030217 neurology & neurosurgery
Computer hardware
Zdroj: Sensors; Volume 18; Issue 1; Pages: 263
Sensors, Vol 18, Iss 1, p 263 (2018)
Sensors (Basel, Switzerland)
ISSN: 1424-8220
DOI: 10.3390/s18010263
Popis: This paper presents a minimally-invasive neural interface for distributed wireless electrocorticogram (ECoG) recording systems. The proposed interface equips all necessary components for ECoG recording, such as the high performance front-end integrated circuits, a fabricated flexible microelectrode array, and wireless communication inside a miniaturized custom-made platform. The multiple units of the interface systems can be deployed to cover a broad range of the target brain region and transmit signals via a built-in intra-skin communication (ISCOM) module. The core integrated circuit (IC) consists of 16-channel, low-power push-pull double-gated preamplifiers, in-channel successive approximation register analog-to-digital converters (SAR ADC) with a single-clocked bootstrapping switch and a time-delayed control unit, an ISCOM module for wireless data transfer through the skin instead of a power-hungry RF wireless transmitter, and a monolithic voltage/current reference generator to support the aforementioned analog and mixed-signal circuit blocks. The IC was fabricated using 250 nm CMOS processes in an area of 3.2 × 0.9 mm2 and achieved the low-power operation of 2.5 µW per channel. Input-referred noise was measured as 5.62 µVrms for 10 Hz to 10 kHz and ENOB of 7.21 at 31.25 kS/s. The implemented system successfully recorded multi-channel neural activities in vivo from a primate and demonstrated modular expandability using the ISCOM with power consumption of 160 µW.
Databáze: OpenAIRE
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