An update on Wnt signaling pathway in cancer

Autor:	Dan Zu, Yanlu Zhang, Zhe Chen, Guoqing Ying
Rok vydání:	2020
Předmět:	Cancer Research Wnt signaling pathway Morphogenesis Cancer Review Article β-catenin Biology medicine.disease Cancer treatment Cell biology inhibitor Multiple factors Oncology Mechanism of action medicine cancer Radiology Nuclear Medicine and imaging medicine.symptom Gene
Zdroj:	Translational Cancer Research
ISSN:	2219-6803 2218-676X
Popis:	Wnt signaling involves many aspects of development, cell biology and physiology. Mutations in the Wnt gene can lead to abnormal embryonic development and cancer formation, including various aspects that affect proliferation, morphogenesis, and differentiation. The occurrence and development of tumors is a complex process involving multiple factors. The Wnt signaling pathway participates in this process as an anti-tumor target by activating multiple gene transcriptions. The emergence of Wnt pathway inhibitors and targeted drugs has opened up a new world of cancer treatment. This review focuses on the mechanism of action of the Wnt signaling pathway in different cancers. Secondly, we have organized and introduced the latest Wnt anti-tumor drugs.
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f67d87b7d786684e3bb00c90c16dce91 https://doi.org/10.21037/tcr.2019.12.50 Zobrazit plný text záznamu