3′-UTR Polymorphisms in the Vascular Endothelial Growth Factor Gene (VEGF) Contribute to Susceptibility to Recurrent Pregnancy Loss (RPL)

Autor: Eun-Gyo Kim, Sung Hwan Cho, Young Ran Kim, Ji Hyang Kim, Hui Jeong An, Chang Soo Ryu, Eun Hee Ahn, Woo Sik Lee, Nam Keun Kim, Jung Oh Kim, Han Sung Park
Jazyk: angličtina
Rok vydání: 2019
Předmět:
0301 basic medicine
Vascular Endothelial Growth Factor A
haplotypes
VEGF 3′-untranslated region
polymorphism
lcsh:Chemistry
chemistry.chemical_compound
single nucleotide polymorphisms
0302 clinical medicine
Gene Frequency
Polymorphism (computer science)
Pregnancy
Medicine
lcsh:QH301-705.5
3' Untranslated Regions
Spectroscopy
030219 obstetrics & reproductive medicine
recurrent pregnancy loss
Incidence
General Medicine
Computer Science Applications
Vascular endothelial growth factor
Female
Adult
Abortion
Habitual
Single-nucleotide polymorphism
Polymorphism
Single Nucleotide
Catalysis
Article
Inorganic Chemistry
Andrology
03 medical and health sciences
Asian People
Humans
Genetic Predisposition to Disease
Physical and Theoretical Chemistry
Molecular Biology
Genetic association
business.industry
Three prime untranslated region
Organic Chemistry
Haplotype
biomarkers
Odds ratio
Genotype frequency
030104 developmental biology
chemistry
lcsh:Biology (General)
lcsh:QD1-999
Case-Control Studies
Linear Models
business
Zdroj: International Journal of Molecular Sciences
International Journal of Molecular Sciences, Vol 20, Iss 13, p 3319 (2019)
Volume 20
Issue 13
ISSN: 1422-0067
Popis: Numerous studies have examined the genetic association of vascular endothelial growth factor (VEGF) single nucleotide polymorphisms (SNPs) with recurrent pregnancy loss (RPL). However, of the four known SNPs in the 3&prime
untranslated region (3&prime
UTR) of VEGF, three SNPs&mdash
namely rs3025040 (1451C>
T), rs10434 (1612G>
A), and rs3025053 (1725G>
A)&mdash
remain poorly characterized with regard to RPL. Herein, we evaluated the association between these three SNPs in the VEGF 3&prime
UTR and RPL susceptibility. We analyzed VEGF 3&prime
UTR gene variants in with and without RPL using TaqMan allelic discrimination. There were significant differences in the genotype frequencies of 1612G>
A (GA: adjusted odds ratio (AOR), 0.652
95% confidence interval (CI), 0.447&ndash
0.951
p = 0.026) and 1725G>
A (GA: AOR, 0.503
95% CI, 0.229&ndash
0.848
p = 0.010) in RPL patients vs. controls. Our results indicate that the 1612G>
A and 1725G>
A polymorphisms in the 3&prime
UTR of VEGF are associated with RPL susceptibility in Korean women. These data suggest that VEGF 3&prime
UTR polymorphisms may be utilized as biomarkers for the detection of RPL risk and prevention.
Databáze: OpenAIRE
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