Anthraquinones from Vismia mexicana
| Autor: | Ricardo Reyes-Chilpa, Silvia Laura Guzmán-Gutiérrez, Antonio Nieto-Camacho, María Guadalupe Campos-Lara, Rocío Gómez-Cansino, Elisa Vega-Avila, Simón Hernández-Ortega |
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| Rok vydání: | 2014 |
| Předmět: |
Natural product
Vismia Magnetic Resonance Spectroscopy biology Molecular Structure Stereochemistry Clusiaceae Anthraquinones DEPT biology.organism_classification Anthraquinone General Biochemistry Genetics and Molecular Biology chemistry.chemical_compound Column chromatography chemistry X-Ray Diffraction Heteronuclear single quantum coherence spectroscopy Chromatography Liquid |
| Zdroj: | Zeitschrift fur Naturforschung. C, Journal of biosciences. 69(1-2) |
| ISSN: | 0939-5075 |
| Popis: | Vismia mexicana (Clusiaceae) is a small tropical tree found from Mexico to Honduras. The CH2Cl2=MeOH extract from the leaves has been reported to have inhibitory properties against reverse transcriptase of human immunodeficiency virus type 1 (HIV-1 RT). In order to characterize some of its chemical constituents, the EtOAc-soluble fraction of this extract was subjected to column chromatography. A new natural product was isolated and designated vismiaquinone D [1-hydroxy-6- methoxy-7,8-(3',3'-dimethyl-pyrano) anthraquinone]. In addition, vismiaquinone was obtained. The structures of vismiaquinone and vismiaquinone D were determined by 1H and 13C NMR spectroscopy, unambiguous assignments were achieved with DEPT, HSQC, and HMBC experiments, and corroborated by X-ray diffraction studies. The isolated anthraquinones were tested against HIV-1 RT. However, none showed relevant activity, suggesting that other compounds in this extract may be responsible for its HIV-1 RT inhibitory properties. |
| Databáze: | OpenAIRE |
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