Low Plasmatic 25-hydroxyvitamin D at Diagnosis is Associated with Axillary Invasion, Chemoresistance and Metastasis in Women with Breast Cancer
| Autor: | Daniel Rech, Durcelina Schiavoni Bortoloti, Pâmella Lonardoni Micheletti, A. C. S. A. Herrera, Andréa Name Colado Simão, Carolina Panis, Vanessa Jacob Victorino, Bruno R. B. Pires, Adma Poliana de Borba Cecílio da Silva, Isaias Dichi, Rodrigo Kern |
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| Rok vydání: | 2020 |
| Předmět: |
0301 basic medicine
Oncology Adult medicine.medical_specialty Poor prognosis Breast Neoplasms Metastasis 03 medical and health sciences 0302 clinical medicine Breast cancer Internal medicine medicine Vitamin D and neurology Humans In patient Neoplasm Invasiveness Neoplasm Metastasis Vitamin D Aged Aged 80 and over business.industry General Medicine Ductal carcinoma Middle Aged medicine.disease Prognosis Peripheral blood Axilla 030104 developmental biology medicine.anatomical_structure Drug Resistance Neoplasm 030220 oncology & carcinogenesis Female business |
| Zdroj: | Archives of medical research. 51(6) |
| ISSN: | 1873-5487 |
| Popis: | Purpose In this study, we investigated the circulating levels of 25-hydroxyvitamin D (25[OH]D) in Brazilian women with breast cancer in samples collected at diagnosis, and correlated these with clinicopathological parameters relevant to disease prognosis. Methods This study involved 147 women diagnosed with infiltrative ductal carcinoma whose peripheral blood samples were collected, to have 25(OH)D levels measured in plasma. Results Our findings indicated that circulating 25(OH)D levels at diagnosis were insufficient in patients with breast cancer. Further, 25(OH)D reduced plasmatic levels at diagnosis correlated significantly with poor prognosis parameters, including axillar positivity, chemoresistance and metastasis. Patients bearing triple-negative tumors also presented reduced 25(OH)D in plasma when compared to those who carried Luminal tumors. Our data suggest relevant correlations when 25(OH)D is reduced in plasma at diagnosis, such as advanced disease with axillar positivity, chemoresistance with advanced disease, early age at diagnosis with high histological grade and dead with axilla positivity. Conclusions: Altogether, our findings reinforce that 25(OH)D reduction can be a plausible marker of disease prognosis in breast cancer. |
| Databáze: | OpenAIRE |
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