Increased IL-33 and IL-17 in Colorectal Carcinoma Patients with Severe Disease
| Autor: | Veljko Maric, Milan Jovanovic, Natasa Zdravkovic, Marina Jovanovic, Nevena Gajovic, Milena Jurisevic, Ivan Jovanovic |
|---|---|
| Rok vydání: | 2020 |
| Předmět: |
il-17
0301 basic medicine medicine.medical_specialty Colorectal cancer il-33 Severe disease Gastroenterology 03 medical and health sciences 0302 clinical medicine colorectal carcinoma Internal medicine medicine kolorektalni karcinom business.industry General Medicine medicine.disease digestive system diseases 3. Good health Interleukin 33 IL-17 030104 developmental biology 030220 oncology & carcinogenesis IL-33 Medicine Interleukin 17 business |
| Zdroj: | Serbian Journal of Experimental and Clinical Research, Vol 21, Iss 3, Pp 239-245 (2020) Serbian Journal of Experimental and Clinical Research (2020) 21(3):239-245 |
| ISSN: | 2335-075X 1820-8665 |
| DOI: | 10.2478/sjecr-2018-0034 |
| Popis: | Colorectal cancer (CRC) represents one of the most common cancers. It is frequently diagnosed at advanced stages, indicating on need for new diagnostic markers. The aim of this study was to determine systemic and fecal values of IL-17 and IL-33 in patients with CRC and the relationship with clinicopathological aspects of disease. The blood samples and feces liquid fraction of 50 patients with CRC were analyzed. Serum and fecal levels of IL-33 and IL-17 were measured using sensitive enzyme-linked immunosorbent assay (ELISA) kits. Fecal levels of Il-33 and IL-17 were increased in CRC patients with poor tumor tissue differentiation. Serum IL-33 and fecal IL-17 were increased in patients with presence of lung/liver metastasis or peritoneal carcinomatosis, respectively, while enhanced fecal IL-33 was detected only in patients with peritoneal carcinomatosis. Positive correlation between IL-33 and IL-17 values in sera and feces, respectively was also observed. We believe that increased local values of IL-33 and IL-17, reflected trough higher fecal concentration, in CRC patients with poor tumor tissue differentiation and with presence of lung/liver metastasis or peritoneal carcinomatosis may be considered as a sign of the tumor’s malignant progression and, consequently, of a poor prognosis for patients. |
| Databáze: | OpenAIRE |
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