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SYNOPSIS. A series of mono-, di- and triesters of oleandomycin and monoesters of erythromycin was tested for bleaching activity on the chloroplast system of Euglena gracilis. Many esters were more active than the original antibiotic base. The most active substances were those with esterification at the neutral sugar oleandrose. The effect of triacetyloleandomycin relative to oleandomycin on Euglena cells correlates directly with its relative antibacterial activity in vivo, while the effect correlates inversely with relative antibacterial activity in vitro. Like the macroorganism, E. gracilis probably accommodates the triester in a manner affording a net, relatively higher concentration of substances to which the chloroplasts are more sensitive. |
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