Small Intestinal Adenomatous Polyposis Resulting in Protein-Losing Enteropathy in a Horse
| Autor: | B. L. Homer, J. C. Patterson-Kane, R. J. MacKay, L. C. Sanchez, J. P. Sundberg |
|---|---|
| Rok vydání: | 2000 |
| Předmět: |
Male
0301 basic medicine Pathology medicine.medical_specialty 040301 veterinary sciences Protein-Losing Enteropathies Columnar Cell Biology Diagnosis Differential 0403 veterinary science Jejunum Adenomatous Polyps Leukocyte Count 03 medical and health sciences Fatal Outcome Ileum Weight Loss medicine Animals Edema Enteropathy Horses Intestinal Mucosa Jejunal Neoplasms General Veterinary Tight junction Protein losing enteropathy Intestinal Polyps Blood Proteins 04 agricultural and veterinary sciences medicine.disease Immunohistochemistry Small intestine Ileal Neoplasms Microscopy Electron 030104 developmental biology medicine.anatomical_structure Hematocrit Small intestinal polyposis Horse Diseases |
| Zdroj: | Veterinary Pathology. 37:82-85 |
| ISSN: | 1544-2217 0300-9858 |
| DOI: | 10.1354/vp.37-1-82 |
| Popis: | A 4-year-old Quarter Horse gelding was presented with a history of weight loss of 6 months duration, along with extensive ventral subcutaneous edema. Clinicopathologic findings included a markedly low serum total protein (2.9 g/dl) and a low packed cell volume (24%). The mucosal surface of the distal jejunum and entire ileum were carpeted with numerous polypoid, papillary, and glandular masses comprised of pseudostratified tall columnar cells and large numbers of interspersed goblet cells. Neoplastic change was diffuse throughout the mucosa of each mass, but abrupt demarcation occurred between neoplastic masses and adjacent mucosa. Immunohistochemical staining for protein of the p53 tumor suppressor gene revealed only occasional cytoplasmic reactivity within polyps and normal mucosa. Nuclear staining for papillomavirus antigens was not observed. Electron microscopic examination revealed features of well-differentiated intestinal epithelial cells, including apical tight junctions and microvilli, desmosomes, and the presence of numerous goblet cells. Microorganisms were not detected. Small intestinal polyposis should be considered as a rare differential diagnosis for protein-losing enteropathy in the horse. |
| Databáze: | OpenAIRE |
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