Enhanced Anti-Diabetogenic Effect of Intravenous Immune Globulin Modified by Ferrous Ion Exposure
| Autor: | Nemanja Zdravkovic, I.K. Djoumerska-Aleksieva, Miodrag L. Lukic, Nada Pejnovic, Tchavdar L. Vassilev, Sladjana Pavlovic, Nebojsa Arsenijevic |
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| Rok vydání: | 2014 |
| Předmět: |
Glycosuria
Type 1 diabetes medicine.medical_specialty Chemistry Pancreatic islets lcsh:R Immunology lcsh:Medicine FOXP3 medicine.disease Proinflammatory cytokine Mononuclear cell infiltration Immune system Therapeutic index Endocrinology medicine.anatomical_structure hemic and lymphatic diseases Internal medicine medicine Immunology and Allergy medicine.symptom |
| Zdroj: | Scopus-Elsevier European Journal of Inflammation, Vol 12 (2014) |
| ISSN: | 2058-7392 |
| Popis: | The aim of this study was to investigate the immunomodulatory capacity of native and Fe(II)-exposed intravenous immune globulin (IVIg) in multiple low dose streptozotocin-induced diabetes and to delineate the mechanisms of their influence on immune cell functions. Optimal doses (200–600mg/kg) of IVIg prevented the development of hyperglycemia, glycosuria and attenuated mononuclear cell infiltration in pancreatic islets. Fe(II) exposure of IVIg decreased their optimal therapeutic dose to 100mg/kg which significantly decreased the serum levels of proinflammatory cytokines compared to the same dose of native IVIg. This was accompanied by lower numbers of TNF-α, IFN-γ and IL-17 producing CD4+ T cells and increased frequencies of CD4+IL-10+ and CD4+IL-4+ T cells in the pancreatic lymph nodes and islets on day 16 after diabetes induction. Ferrous ion-exposed IVIg enhanced the bias towards Th2 response while the regulatory Foxp3+ T cells were not affected. |
| Databáze: | OpenAIRE |
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