Clinical significance of the detection of Candida albicans germ tube-specific antibodies in critically ill patients
| Autor: | R, Zaragoza, J, Pemán, G, Quindós, J R, Iruretagoyena, M S, Cuétara, P, Ramírez, M D, Gómez, J J, Camarena, A, Viudes, J, Pontón, M J, Linares-Sicilia |
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| Rok vydání: | 2009 |
| Předmět: |
Adult
Male Microbiology (medical) medicine.medical_specialty Antigens Fungal Adolescent Critical Illness critically ill patients Germ tube pre-emptive antifungal therapy Antibodies law.invention law Intensive care Internal medicine Candida albicans polycyclic compounds medicine Humans Clinical significance Antibodies Fungal Mycosis Aged Aged 80 and over biology business.industry Mortality rate General Medicine Middle Aged invasive candidiasis biochemical phenomena metabolism and nutrition bacterial infections and mycoses medicine.disease biology.organism_classification mortality Intensive care unit Hospitals Confidence interval Surgery Infectious Diseases Spain ICU bacteria Female business Candida germ tube |
| Zdroj: | CLINICAL MICROBIOLOGY AND INFECTION r-IIS La Fe. Repositorio Institucional de Producción Científica del Instituto de Investigación Sanitaria La Fe instname |
| ISSN: | 1198-743X |
| DOI: | 10.1111/j.1469-0691.2009.02794.x |
| Popis: | The present study, comprising a prospective multicentre study including 53 non-neutropenic patients from intensive care units (ICU) in six Spanish tertiary-care hospitals, was carried out to determine the clinical significance and influence on mortality of Candida albicans germ tube-specific antibodies (CAGTA). There were 22 patients (41.5%) for whom the CAGTA results were positive, although none of had a blood culture positive for Candida . The intra-ICU mortality rate was significantly lower (p = 0.004) in CAGTA-positive patients (61.2% vs. 22.7%). Multivariate analysis confirmed that a positive CAGTA result was the only protective factor to be independently associated with ICU mortality ( β coefficient=−0.3856; 95% confidence interval=−0.648 to −0.123). |
| Databáze: | OpenAIRE |
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