Quality evaluation of health foods containing licorice in the Japanese Market
| Autor: | T Kawano, Jun Yamauchi, Yoshiko Ishimi, Hiroyuki Fuchino, Jun Takebayashi, Nobuo Kawahara, Yuko Tousen, Kayo Yoshimatsu, Takayuki Inui |
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| Rok vydání: | 2019 |
| Předmět: |
FOSHU
Foods for Specified Health Uses Health Toxicology and Mutagenesis BMD bone mineral density Health foods Estrogenic activity 010501 environmental sciences Toxicology 01 natural sciences Article TE Trolox equivalent Licorice 03 medical and health sciences chemistry.chemical_compound 0302 clinical medicine lcsh:RA1190-1270 Herbal medicines Medicine CAA Consumer Affairs Agency Health food Glycyrrhizin lcsh:Toxicology. Poisons ComputingMethodologies_COMPUTERGRAPHICS 0105 earth and related environmental sciences FFC Foods with Function Claims FNFC Foods with Nutrient Functional Claim Postmenopausal women Traditional medicine biology business.industry Hepatic cytochrome ORAC oxygen radical absorption capacity DGL deglycyrrhizin biology.organism_classification Cytochrome P-450 (CYP) Japanese market chemistry Safety assessment HPLC high-performance liquid chromatography CYP cytochrome P-450 Ovariectomized rat Glycyrrhiza business E2 17β-estradiol 030217 neurology & neurosurgery Glabridin |
| Zdroj: | Toxicology Reports Toxicology Reports, Vol 6, Iss, Pp 904-913 (2019) |
| ISSN: | 2214-7500 |
| DOI: | 10.1016/j.toxrep.2019.08.013 |
| Popis: | Graphical abstract Highlights • The contents of glabridin and medical component glycyrrhizin were analyzed in herbal medicines and health foods containing licorice. • A small amount of glycyrrhizin was detected in some of health foods. • Estrogenic activity was detected in some of health food ingredients and health foods. • Antioxidant activity was detected in all the materials. • Hepatic CYP activity, liver and uterine weights in estrogen deficient mice are also valuable for the safety evaluation of estrogenic ingredients. Focusing on licorice, a highly used raw material in health foods, quantitative analysis of functional/medicinal components and a safety and functional evaluation was carried out for herbal medicines, health food ingredients, and so-called health foods. A functional component, glabridin, was detected in herbal medicines from Glycyrrhiza glabra and G. inflata, health food ingredients, and in commercially available health foods that contain licorice. Likewise, glycyrrhizin, a medicinal component, was detected in these sources, except in licorice oil extract. Estrogen activity in vitro was detected in some of the herbal medicines, health food ingredients, and in health foods containing licorice. In the in vivo study, liver weight in ovariectomized (OVX) mice treated with licorice oil extract was significantly higher than that in OVX and sham mice in a dose dependent manner. These results suggest that excessive intake of licorice oil extract from health foods should be avoided, even though these ingredients might be beneficial for medical use in order to maintain bone health in postmenopausal women. Measurement of hepatic cytochrome P-450 (CYP) activity, reproductive organ weight, and fat and bone mass in OVX mice was considered useful for evaluating the safety and efficacy of estrogenic health food ingredients derived from herbal medicines. |
| Databáze: | OpenAIRE |
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