Advances on hormone-like activity of Panax ginseng and ginsenosides
| Autor: | Lin-Nan Li, Li Yang, Zhengtao Wang, Rui-Rong Zheng, Mei Tian |
|---|---|
| Rok vydání: | 2020 |
| Předmět: |
Ginsenosides
medicine.medical_treatment Panax Traditional Chinese medicine complex mixtures 01 natural sciences Steroid 03 medical and health sciences Ginseng chemistry.chemical_compound 0302 clinical medicine Drug Discovery medicine Animals Humans Medicine Chinese Traditional Molecular Structure biology Traditional medicine 010405 organic chemistry Dammarane food and beverages General Medicine biology.organism_classification Hormones 0104 chemical sciences Steroid hormone Aglycone Complementary and alternative medicine chemistry 030220 oncology & carcinogenesis Araliaceae Signal Transduction Hormone |
| Zdroj: | Chinese Journal of Natural Medicines. 18:526-535 |
| ISSN: | 1875-5364 |
| DOI: | 10.1016/s1875-5364(20)30063-7 |
| Popis: | Traditional Chinese medicine (TCM) has been paid much attentions due to the prevention and treatment of steroid hormone disorders. Ginseng, the root of Panax ginseng C. A. Meyer (Araliaceae), is one of the most valuable herbs in complementary and alternative medicines around the world. A series of dammarane triterpenoid saponins, also known as phytosteroids, were reported as the primary ingredients of Ginseng, and indicated broad spectral pharmacological actions, including anti-cancer, anti-inflammation and anti-fatigue. The skeletons of the dammarane triterpenoid aglycone are structurally similar to the steroid hormones. Both in vitro and in vivo studies showed that Ginseng and its active ingredients have beneficial hormone-like role in hormonal disorders. This review thus summarizes the structural similarities between hormones and dammarane ginsenosides and integrates the analogous effect of Ginseng and ginsenosides on prevention and treatment of hormonal disorders published in recent twenty years (1998-2018). The review may provide convenience for anticipate structure-function relationship between saponins structure and hormone-like effect. |
| Databáze: | OpenAIRE |
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