Long-term physical activity leads to a significant increase in serum sRAGE levels: a sign of decreased AGE-mediated inflammation due to physical activity?

Autor: Brigitte Litschauer, Senta Graf, Michael Emich, Jeanette Strametz-Juranek, Monika Fritzer-Szekeres, Michael Sponder, Ioana-Alexandra Campean, Daniel Dalos
Rok vydání: 2018
Předmět:
Adult
Glycation End Products
Advanced
Male
medicine.medical_specialty
Time Factors
Receptor for Advanced Glycation End Products
Observation period
Increased physical activity
Physical activity
Enzyme-Linked Immunosorbent Assay
030209 endocrinology & metabolism
Inflammation
030204 cardiovascular system & hematology
03 medical and health sciences
0302 clinical medicine
Glycation
Internal medicine
Humans
Medicine
Prospective Studies
Advanced glycation end products
Prospective cohort study
Exercise
Aged
biology
business.industry
Lipoprotein(a)
Middle Aged
RAGE
Endocrinology
Cardiovascular Diseases
Exercise Test
biology.protein
Original Article
Female
Multiple linear regression analysis
Inflammation Mediators
medicine.symptom
Cardiology and Cardiovascular Medicine
business
Biomarkers
sRAGE
Follow-Up Studies
Zdroj: Heart and Vessels
ISSN: 1615-2573
0910-8327
Popis: There is growing evidence that low levels of the circulating soluble receptor of advanced glycation end products (sRAGE) are a valuable predictor of cardiovascular disease (CVD). The aim of this prospective study was to investigate the influence of long-term physical activity on serum sRAGE levels. 109 subjects were recruited, and 98 completed the study. Participants were asked to perform exercise within the calculated training pulse for 8 months. The performance gain was measured/quantified by bicycle stress tests at the beginning and end of the observation period. sRAGE was measured at baseline and after 2/6/8 months by ELISA. Backwards, multiple linear regression analysis was performed to investigate the association of co-variables age, sex, BMI, and performance at baseline, HbA1c, and lipoprotein a with baseline sRAGE levels. We identified BMI and lipoprotein a as significant predictors for baseline sRAGE levels. Compared to subjects with a performance gain ≤ 4.9% subjects with a gain > 5% showed a significant increase in sRAGE levels up to 22%. sRAGE serum levels correlate negatively with lipoprotein a levels and BMI and long-term physical activity leads to a significant increase in serum sRAGE levels (9–22%), whereby the sRAGE increase is most pronounced in subjects with initially low-performance levels, suggesting that in particular, these subject profit the most from increased physical activity. The sport-mediated increase of sRAGE might be a sign of decreased AGE-mediated inflammation and highlight the protective effect of sports on CVD and other disease which are at least partly mediated by an increased inflammation status.Clinical trials registration NCT02097199.
Databáze: OpenAIRE
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