A laminin 511 matrix is regulated by TAZ and functions as the ligand for the α6Bβ1 integrin to sustain breast cancer stem cells
| Autor: | Arthur M. Mercurio, Elgene Lim, Manuel Patarroyo, Karen K. McKee, Dale L. Greiner, Hira Lal Goel, Shiliang Cao, Junhao Mao, Cheng Chang, Sulev Ingerpuu, Bryan M. Pursell, Leonard D. Shultz, Peter D. Yurchenco, Huijie Gao |
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| Rok vydání: | 2015 |
| Předmět: |
medicine.medical_specialty
Integrin Breast Neoplasms Tumor initiation Ligands Extracellular matrix Research Communication Breast cancer Cancer stem cell Laminin Internal medicine Genetics medicine Humans skin and connective tissue diseases Transcription factor Integrin alpha6beta1 biology Intracellular Signaling Peptides and Proteins medicine.disease Extracellular Matrix Cell biology Endocrinology Transcriptional Coactivator with PDZ-Binding Motif Proteins Neoplastic Stem Cells Trans-Activators biology.protein Female sense organs Stem cell Transcription Factors Developmental Biology |
| Zdroj: | Genes & Development. 29:1-6 |
| ISSN: | 1549-5477 0890-9369 |
| Popis: | Understanding how the extracellular matrix impacts the function of cancer stem cells (CSCs) is a significant but poorly understood problem. We report that breast CSCs produce a laminin (LM) 511 matrix that promotes self-renewal and tumor initiation by engaging the α6Bβ1 integrin and activating the Hippo transducer TAZ. Although TAZ is important for the function of breast CSCs, the mechanism is unknown. We observed that TAZ regulates the transcription of the α5 subunit of LM511 and the formation of a LM511 matrix. These data establish a positive feedback loop involving TAZ and LM511 that contributes to stemness in breast cancer. |
| Databáze: | OpenAIRE |
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