Pulmonary function at follow-up of very preterm infants from the United Kingdom oscillation study
| Autor: | Neil Marlow, Anthony D Milner, Anne Greenough, Gerrard F. Rafferty, Mark R Thomas, Sandra Calvert, Janet L. Peacock, E. S. Limb |
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| Rok vydání: | 2003 |
| Předmět: |
Pulmonary and Respiratory Medicine
Male Respiratory rate medicine.medical_treatment High-Frequency Ventilation Critical Care and Intensive Care Medicine Statistics Nonparametric Pulmonary function testing Functional residual capacity Airway resistance Medicine Humans Lung volumes Bronchopulmonary Dysplasia business.industry High-frequency ventilation Infant Newborn Infant medicine.disease United Kingdom Respiratory Function Tests Bronchopulmonary dysplasia Anesthesia Helium dilution technique Respiratory Mechanics Female business Infant Premature Follow-Up Studies |
| Zdroj: | American journal of respiratory and critical care medicine. 169(7) |
| ISSN: | 1073-449X |
| Popis: | Prematurely born infants supported by conventional ventilation (CV) frequently have abnormal pulmonary function when assessed in childhood. The aim of this study was to test the hypothesis that infants who were randomly assigned to high-frequency oscillatory ventilation would have superior pulmonary function at follow-up compared with those who received CV (UK Oscillation Study). Infants from 12 trial centers were recruited for pulmonary function testing at a single center. Seventy-six infants, of a mean gestational age 26.4 weeks, were studied after sedation with chloral hydrate at between 11 and 14 months of age, corrected for prematurity. Infants assigned to CV had similar pulmonary function compared with those assigned to high-frequency oscillatory ventilation, with mean (SD) results as follows: functional residual capacity measured by whole-body plethysmography, 26.9 (6.3) versus 26.5 (6.4) ml/kg; functional residual capacity measured by helium dilution, 24.1 (5.4) versus 23.5 (5.7) ml/kg; inspiratory airway resistance, 3.3 (1.3) versus 3.4 (1.6) kPa. second. L; expiratory airway resistance, 4.4 (2.8) versus 4.1 (2.5) kPa. second. L; respiratory rate, 31.2 (6.0) versus 33.9 (8.0) breaths/minute. We conclude that early use of high-frequency oscillatory ventilation in very preterm infants appears to offer no advantage over CV in terms of pulmonary function at follow-up. |
| Databáze: | OpenAIRE |
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