Mitochondria: new players in homeostatic regulation of firing rate set points
| Autor: | Maxim Katsenelson, Inna Slutsky, Antonella Ruggiero |
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| Rok vydání: | 2021 |
| Předmět: |
Neurons
0301 basic medicine Neuronal Plasticity General Neuroscience Mitochondrion Biology Synaptic vesicle Homeostatic Process Calcium in biology Mitochondria 03 medical and health sciences 030104 developmental biology 0302 clinical medicine Biological neural network Homeostasis Humans Wakefulness Signal transduction Sleep Neuroscience 030217 neurology & neurosurgery |
| Zdroj: | Trends in Neurosciences |
| ISSN: | 0166-2236 |
| Popis: | Neural circuit functions are stabilized by homeostatic processes at long timescales in response to changes in behavioral states, experience, and learning. However, it remains unclear which specific physiological variables are being stabilized and which cellular or neural network components compose the homeostatic machinery. At this point, most evidence suggests that the distribution of firing rates among neurons in a neuronal circuit is the key variable that is maintained around a set-point value in a process called 'firing rate homeostasis.' Here, we review recent findings that implicate mitochondria as central players in mediating firing rate homeostasis. While mitochondria are known to regulate neuronal variables such as synaptic vesicle release or intracellular calcium concentration, the mitochondrial signaling pathways that are essential for firing rate homeostasis remain largely unknown. We used basic concepts of control theory to build a framework for classifying possible components of the homeostatic machinery that stabilizes firing rate, and we particularly emphasize the potential role of sleep and wakefulness in this homeostatic process. This framework may facilitate the identification of new homeostatic pathways whose malfunctions drive instability of neural circuits in distinct brain disorders. |
| Databáze: | OpenAIRE |
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