Decline in serum antibodies to methyltetrahydrophthalic anhydride after cessation of exposure.Implications for use as a biomarker

Autor:	S. Skerfving, I. Bensryd, J. Nielsen, U. Stromberg, B. Bjork, Hans Welinder
Rok vydání:	1998
Předmět:	biology Chemistry Health Toxicology and Mutagenesis Clinical Biochemistry Total ige medicine.disease Immunoglobulin E Biochemistry Atopy Specific antibody Immunology Methyltetrahydrophthalic anhydride medicine biology.protein Biomarker (medicine) Antibody Half time
Zdroj:	Biomarkers. 3:141-148
ISSN:	1366-5804 1354-750X
DOI:	10.1080/135475098231291
Popis:	T he association between exposure intensity and serum levels of immunoglobulins E and G against low molecular weight compounds was evaluated. The decay of levels of specific IgE and IgG antibodies was studied after cessation of exposure in workers exposed to the inhalant allergen methyltetrahydrophthalic anhydride in a plant using epoxy resins. Sera have been collected in workers for 18-84 (mean value 54) months after cessation of exposure. Specific IgE and IgG was assessed by RAST and ELISA, respectively. The mean of individual half-times for IgE (N = 10) and IgG (N = 8) was 0 9 (range 0 1-1 8) and 0 4 (range 0 2-0 6) years, respectively, after total avoidance of exposure. Corresponding decreases of IgE and IgG were also observed after reduction, but not total elimination, of exposure. No correlation was seen between biologic halftimes of specific IgE and total IgE, atopy, smoking habits or gender. The results indicate that the levels of specific antibodies in sensitized individuals reflect long term exposure, and may persist for years after the end of exposure.
Databáze:	OpenAIRE
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