Inhibition of the interactions between eukaryotic initiation factors 4E and 4G impairs long-term associative memory consolidation but not reconsolidation
Autor: | Edvin Klosi, Nathan J. Moerke, Gerhard Wagner, Elizabeth C. Arnold, Michael Chorev, Eric Klann, Richard E. Lloyd, Charles A. Hoeffer, Philippe Pierre, Ricard A. Rodriguez, Enrico K. Schmidt, Joseph E. LeDoux, Jessica L. Banko, Kiriana K. Cowansage |
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Přispěvatelé: | New York University School of Medicine (NYU), New York University School of Medicine, NYU System (NYU)-NYU System (NYU), Pfizer Global Research and Development, Neuroscience Research Unit, University of South Florida [Tampa] (USF), Department of Biological Chemistry and Molecular Pharmacology (HMS), Harvard Medical School [Boston] (HMS), Centre d'Immunologie de Marseille - Luminy (CIML), Institut National de la Santé et de la Recherche Médicale (INSERM)-Centre National de la Recherche Scientifique (CNRS)-Aix Marseille Université (AMU), Baylor College of Medicine (BCM), Baylor University, Aix Marseille Université (AMU)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Centre National de la Recherche Scientifique (CNRS) |
Jazyk: | angličtina |
Rok vydání: | 2011 |
Předmět: |
Male
Fear memory Memory Long-Term MESH: Rats MESH: Rats Sprague-Dawley Biology Bioinformatics Rats Sprague-Dawley 03 medical and health sciences 0302 clinical medicine Eukaryotic initiation factor MESH: Amygdala Protein biosynthesis MESH: Memory Long-Term Animals MESH: Protein Binding MESH: Animals MESH: Neuronal Plasticity 030304 developmental biology Protein Synthesis Inhibitors 0303 health sciences Neuronal Plasticity Multidisciplinary Consolidation (soil) MESH: Protein Synthesis Inhibitors Translation (biology) MESH: Eukaryotic Initiation Factor-4G Biological Sciences Content-addressable memory Amygdala MESH: Eukaryotic Initiation Factor-4E MESH: Male Rats Blockade Eukaryotic Initiation Factor-4E Protein Biosynthesis MESH: Protein Biosynthesis [SDV.IMM]Life Sciences [q-bio]/Immunology Memory consolidation Eukaryotic Initiation Factor-4G Neuroscience 030217 neurology & neurosurgery Protein Binding |
Zdroj: | Proceedings of the National Academy of Sciences of the United States of America Proceedings of the National Academy of Sciences of the United States of America, National Academy of Sciences, 2011, 108 (8), pp.3383-8. ⟨10.1073/pnas.1013063108⟩ Proceedings of the National Academy of Sciences of the United States of America, 2011, 108 (8), pp.3383-8. ⟨10.1073/pnas.1013063108⟩ |
ISSN: | 0027-8424 1091-6490 |
DOI: | 10.1073/pnas.1013063108⟩ |
Popis: | International audience; Considerable evidence indicates that the general blockade of protein synthesis prevents both the initial consolidation and the postretrieval reconsolidation of long-term memories. These findings come largely from studies of drugs that block ribosomal function, so as to globally interfere with both cap-dependent and -independent forms of translation. Here we show that intra-amygdala microinfusions of 4EGI-1, a small molecule inhibitor of cap-dependent translation that selectively disrupts the interaction between eukaryotic initiation factors (eIF) 4E and 4G, attenuates fear memory consolidation but not reconsolidation. Using a combination of behavioral and biochemical techniques, we provide both in vitro and in vivo evidence that the eIF4E-eIF4G complex is more stringently required for plasticity induced by initial learning than for that triggered by reactivation of an existing memory. |
Databáze: | OpenAIRE |
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