Inhibition of the interactions between eukaryotic initiation factors 4E and 4G impairs long-term associative memory consolidation but not reconsolidation

Autor: Edvin Klosi, Nathan J. Moerke, Gerhard Wagner, Elizabeth C. Arnold, Michael Chorev, Eric Klann, Richard E. Lloyd, Charles A. Hoeffer, Philippe Pierre, Ricard A. Rodriguez, Enrico K. Schmidt, Joseph E. LeDoux, Jessica L. Banko, Kiriana K. Cowansage
Přispěvatelé: New York University School of Medicine (NYU), New York University School of Medicine, NYU System (NYU)-NYU System (NYU), Pfizer Global Research and Development, Neuroscience Research Unit, University of South Florida [Tampa] (USF), Department of Biological Chemistry and Molecular Pharmacology (HMS), Harvard Medical School [Boston] (HMS), Centre d'Immunologie de Marseille - Luminy (CIML), Institut National de la Santé et de la Recherche Médicale (INSERM)-Centre National de la Recherche Scientifique (CNRS)-Aix Marseille Université (AMU), Baylor College of Medicine (BCM), Baylor University, Aix Marseille Université (AMU)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Centre National de la Recherche Scientifique (CNRS)
Jazyk: angličtina
Rok vydání: 2011
Předmět:
Male
Fear memory
Memory
Long-Term

MESH: Rats
MESH: Rats
Sprague-Dawley

Biology
Bioinformatics
Rats
Sprague-Dawley

03 medical and health sciences
0302 clinical medicine
Eukaryotic initiation factor
MESH: Amygdala
Protein biosynthesis
MESH: Memory
Long-Term

Animals
MESH: Protein Binding
MESH: Animals
MESH: Neuronal Plasticity
030304 developmental biology
Protein Synthesis Inhibitors
0303 health sciences
Neuronal Plasticity
Multidisciplinary
Consolidation (soil)
MESH: Protein Synthesis Inhibitors
Translation (biology)
MESH: Eukaryotic Initiation Factor-4G
Biological Sciences
Content-addressable memory
Amygdala
MESH: Eukaryotic Initiation Factor-4E
MESH: Male
Rats
Blockade
Eukaryotic Initiation Factor-4E
Protein Biosynthesis
MESH: Protein Biosynthesis
[SDV.IMM]Life Sciences [q-bio]/Immunology
Memory consolidation
Eukaryotic Initiation Factor-4G
Neuroscience
030217 neurology & neurosurgery
Protein Binding
Zdroj: Proceedings of the National Academy of Sciences of the United States of America
Proceedings of the National Academy of Sciences of the United States of America, National Academy of Sciences, 2011, 108 (8), pp.3383-8. ⟨10.1073/pnas.1013063108⟩
Proceedings of the National Academy of Sciences of the United States of America, 2011, 108 (8), pp.3383-8. ⟨10.1073/pnas.1013063108⟩
ISSN: 0027-8424
1091-6490
DOI: 10.1073/pnas.1013063108⟩
Popis: International audience; Considerable evidence indicates that the general blockade of protein synthesis prevents both the initial consolidation and the postretrieval reconsolidation of long-term memories. These findings come largely from studies of drugs that block ribosomal function, so as to globally interfere with both cap-dependent and -independent forms of translation. Here we show that intra-amygdala microinfusions of 4EGI-1, a small molecule inhibitor of cap-dependent translation that selectively disrupts the interaction between eukaryotic initiation factors (eIF) 4E and 4G, attenuates fear memory consolidation but not reconsolidation. Using a combination of behavioral and biochemical techniques, we provide both in vitro and in vivo evidence that the eIF4E-eIF4G complex is more stringently required for plasticity induced by initial learning than for that triggered by reactivation of an existing memory.
Databáze: OpenAIRE