Ranitidine is associated with infections, necrotizing enterocolitis, and fatal outcome in newborns
| Autor: | Terrin G., Passariello A., De Curtis M., Manguso F., Salvia G., Lega L., Messina F., Paludetto R., BERNI CANANI, ROBERTO, PASSARIELLO, ANNALISA |
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| Přispěvatelé: | Terrin, G., Passariello, A., De Curtis, M., Manguso, F., Salvia, G., Lega, L., Messina, F., Paludetto, R., BERNI CANANI, Roberto, Passariello, Annalisa |
| Rok vydání: | 2011 |
| Předmět: |
Male
Pediatrics medicine.medical_specialty Peptic Ulcer histamine-2 receptor antagonists Birth weight very low birth weight Infant Premature Diseases Neonatal age Ranitidine sepsis Gastric Acid Enterocolitis Necrotizing Risk Factors Intensive care gastric acidity inhibitors medicine urinary tract infections microflora pneumonia Humans Infant Very Low Birth Weight Enterocolitis business.industry Infant Newborn Gestational age Bacterial Infections medicine.disease Anti-Ulcer Agents Surgery Low birth weight Histamine H2 Antagonists Pediatrics Perinatology and Child Health Necrotizing enterocolitis Female medicine.symptom business Infant Premature medicine.drug |
| Zdroj: | Pediatrics. 129(1) |
| ISSN: | 1098-4275 |
| Popis: | Background And Objective:Gastric acidity is a major nonimmune defense mechanism against infections. The objective of this study was to investigate whether ranitidine treatment in very low birth weight (VLBW) infants is associated with an increased risk of infections, necrotizing enterocolitis (NEC), and fatal outcome.Methods:Newborns with birth weight between 401 and 1500 g or gestational age between 24 and 32 weeks, consecutively observed in neonatal intensive care units, were enrolled in a multicenter prospective observational study. The rates of infectious diseases, NEC, and death in enrolled subjects exposed or not to ranitidine were recorded.Results:We evaluated 274 VLBW infants: 91 had taken ranitidine and 183 had not. The main clinical and demographic characteristics did not differ between the 2 groups. Thirty-four (37.4%) of the 91 children exposed to ranitidine and 18 (9.8%) of the 183 not exposed to ranitidine had contracted infections (odds ratio 5.5, 95% confidence interval 2.9–10.4, P < .001). The risk of NEC was 6.6-fold higher in ranitidine-treated VLBW infants (95% confidence interval 1.7–25.0, P = .003) than in control subjects. Mortality rate was significantly higher in newborns receiving ranitidine (9.9% vs 1.6%, P = .003).Conclusions:Ranitidine therapy is associated with an increased risk of infections, NEC, and fatal outcome in VLBW infants. Caution is advocated in the use of this drug in neonatal age. |
| Databáze: | OpenAIRE |
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