Epigenetic regulation of neural stem cell fate during corticogenesis
| Autor: | Berry Juliandi, Chai MuhChyi, Taito Matsuda, Kinichi Nakashima |
|---|---|
| Rok vydání: | 2013 |
| Předmět: |
Cerebral Cortex
Epigenomics Neurons Multipotent Stem Cells Neurogenesis Neural tube EMX1 Biology Neural stem cell nervous system diseases Corticogenesis medicine.anatomical_structure nervous system Developmental Neuroscience Cerebral cortex medicine Animals biological phenomena cell phenomena and immunity Neuroscience Neural cell reproductive and urinary physiology Developmental Biology Gliogenesis |
| Zdroj: | International Journal of Developmental Neuroscience. 31:424-433 |
| ISSN: | 1873-474X 0736-5748 |
| DOI: | 10.1016/j.ijdevneu.2013.02.006 |
| Popis: | The cerebral cortex comprises over three quarters of the brain, and serves as structural basis for the sophisticated perceptual and cognitive functions. It develops from common multipotent neural stem cells (NSCs) that line the neural tube. Development of the NSCs encompasses sequential phases of progenitor expansion, neurogenesis, and gliogenesis along with the progression of developmental stages. Interestingly, NSCs steadfastly march through all of these phases and give rise to specific neural cell types in a temporally defined and highly predictable manner. Herein, we delineate the intrinsic and extrinsic factors that dictate the progression and tempo of NSC differentiation during cerebral cortex development, and how epigenetic modifications contribute to the dynamic properties of NSCs. |
| Databáze: | OpenAIRE |
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