Expression of cell cycle-regulated proteins pRB2/p130, p107, E2F4, p27, and pCNA in salivary gland tumors: prognostic and diagnostic implications
| Autor: | Pier Paolo Claudio, Alessandra Zamparelli, Giuseppe Russo, Lorenzo Leoncini, Cristiana Bellan, Antonio Giordano, Giovanna Carillo, Corrado Minimo, Luigi Califano, Candace M. Howard |
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| Rok vydání: | 2005 |
| Předmět: |
Adult
Male Cancer Research Pathology medicine.medical_specialty Cell Cycle Proteins Retinoblastoma-Like Protein p107 E2F4 Transcription Factor Metastasis Proliferating Cell Nuclear Antigen medicine Biomarkers Tumor Humans Grading (tumors) Aged Salivary gland biology Retinoblastoma-Like Protein p130 Retinoblastoma Endometrial cancer Tumor Suppressor Proteins Nuclear Proteins Proteins Cell cycle Middle Aged medicine.disease Prognosis Salivary Gland Neoplasms Immunohistochemistry Proliferating cell nuclear antigen E2F Transcription Factors DNA-Binding Proteins medicine.anatomical_structure Oncology embryonic structures biology.protein Female biological phenomena cell phenomena and immunity Cyclin-Dependent Kinase Inhibitor p27 Follow-Up Studies Transcription Factors |
| Zdroj: | Clinical cancer research : an official journal of the American Association for Cancer Research. 11(9) |
| ISSN: | 1078-0432 |
| Popis: | The retinoblastoma family consists of the tumor suppressor nuclear phosphoprotein pRb/p105 and related proteins p107 and pRb2/p130. Recent immunohistochemical studies of the retinoblastoma family of proteins in lung and endometrial cancer and choroidal melanomas show a tight inverse correlation between the histologic grading in the most aggressive tumor types and pRb2/p130 expression. This led us to investigate the role of pRb2/p130 in salivary tumors. We studied the expression of pRb2/p130, p107, E2F4, p27, and PcNA by immunohistochemistry in a panel of 44 salivary gland tumors. We found a direct correlation between the cytoplasmic expression of pRb2/p130 and tumor grading and the presence of metastasis that was highly statistically significant (P < 0.001). Additionally, increased cytoplasmic pRb2/p130 expression was significantly correlated with a decreased probability of survival (P < 0.001). Interestingly, p107 nuclear expression showed a strong direct correlation when compared with the same variables. pRb2/p130 showed the highest percentage of undetectable nuclear levels in the specimens examined and the tightest inverse correlation (P < 0.0001) with both the histologic grading and pCNA expression in malignant salivary tumors. Additionally, E2F4 showed an identical localization pattern as to that of pRb2/p130. These data suggests an important role for pRb2/p130 in the pathogenesis and progression of certain salivary gland cancers. |
| Databáze: | OpenAIRE |
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