The anterior eye chamber: entry of the natural excretion pathway of gadolinium contrast agents?
| Autor: | Katerina Deike-Hofmann, Paula von Lampe, Alexander Radbruch, Michael Forsting, Heinz-Peter Schlemmer, Nikolaos E. Bechrakis, Christoph Kleinschnitz |
|---|---|
| Jazyk: | angličtina |
| Rok vydání: | 2020 |
| Předmět: |
Gadolinium DTPA
Male medicine.medical_specialty Anterior Chamber Retinal Neoplasms Gadolinium Medizin Contrast Media chemistry.chemical_element Gadolinium contrast Excretion Meglumine Interquartile range Patient age Organometallic Compounds Humans Medicine Radiology Nuclear Medicine and imaging Retrospective Studies Neuroradiology medicine.diagnostic_test business.industry Ultrasound Infant Newborn Retinoblastoma Infant Magnetic resonance imaging General Medicine Magnetic Resonance Imaging chemistry Child Preschool Injections Intravenous Female Radiology business Nuclear medicine |
| Popis: | Previous studies provided evidence that gadolinium can be found in the aqueous chamber (AC) of the eye several hours post injection (p.i.) of gadolinium-based contrast agents (GBCAs). This study aimed to investigate whether gadolinium can be detected promptly after injection of a macrocyclic GBCA on contrast-enhanced T1-weighted MRI in the AC of children. This retrospective study encompassed MRI of 200 healthy eyes of children suffering from retinoblastoma of the contralateral eye. MRI was performed with an orbital coil with the children in a state of general anesthesia. Differences of signal intensity ratios (∆SIRs) of the AC to the lens were determined between pre and post contrast-enhanced T1-weighted images (Dotarem®, Guerbet, 0.1 ml/kg body weight, mean (standard deviation) p.i. time = 12:24 (± 2:31) min). A highly significant signal intensity increase was found in the AC of healthy eyes 12 min after GBCA injection (median ∆SIR (interquartile range) = + 0.08 (0.05–0.12), p |
| Databáze: | OpenAIRE |
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