Role of therapeutic plasma exchange in acute humoral rejection patients undergoing live-related renal transplantation: A single-center experience
| Autor: | Sweta Nayak, Sanjiv Jasuja, Sandeep Guleria, Gaurav Sagar, Raj Nath Makroo, Brinda Kakkar, Mohit Chowdhry, Soma Agrawal |
|---|---|
| Jazyk: | angličtina |
| Rok vydání: | 2021 |
| Předmět: |
medicine.medical_specialty
Creatinine business.industry acute humoral rejection medicine.medical_treatment Urology graft survival Hematology renal transplantation Single Center Transplantation therapeutic plasma exchange chemistry.chemical_compound chemistry Renal allograft Immunology and Allergy Medicine Population study Therapeutic plasma exchange Graft survival Original Article Diseases of the blood and blood-forming organs Renal replacement therapy RC633-647.5 business |
| Zdroj: | Asian Journal of Transfusion Science, Vol 15, Iss 1, Pp 62-67 (2021) Asian Journal of Transfusion Science |
| ISSN: | 1998-3565 0973-6247 |
| Popis: | Background and Aim: Renal transplantation (RT) is the most successful and ideal renal replacement therapy for end-stage renal disease patients. Renal allograft rejection has always been one of the major barriers in successful RT. Our aim was to report the role of therapeutic plasma exchange (TPE) in acute humoral rejection (AHR) patients who underwent live-related RT (LRRT) and their renal allograft outcome at our center. Materials and Methods: A prospective observational study was conducted from July 1, 2014, to December 31, 2016. Patients with biopsy-proven AHR and treated with TPE along with other lines of treatment after undergoing LRRT were included in the study. ABO-incompatible individuals, pediatric patients, and patients undergoing second transplants were excluded from the study. Clinical history, donor and graft details, management, and patient and graft survival were noted. Results: Of the 1608 patients who underwent LRRT, 49 (37 males, 76%; 12 females, 24%; mean age 39.5 ± 13.3 years) had biopsy-proven AHR (3.04%) and were treated with TPE. A total of 281 TPEs were performed with an average of 5.7 TPE/patient (range 2–12). Of the 49 patients, 38 patients (78%) with favorable response underwent 213 (75.8%) TPEs (average of 5.6 TPE/patient; range: 2–12), whereas 11 patients (22%) with unfavorable response underwent 68 (24.2%) TPEs (average of 6.2 TPE/patient; range: 3–8). Blood urea (P = 0.012) and serum creatinine (P = 0.038) levels at the time of rejection were significant predictors of response to TPE therapy. The average length of stay in our study population was 33 ± 22 days. Six months posttransplant, the patient and graft survival were 93.3% and 89.5%, whereas at 12 months, they were 89.3% and 81.5%, respectively. Conclusion: TPE is a safe and effective adjunct therapy for treating AHR patients. |
| Databáze: | OpenAIRE |
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