Chinese Data of Efficacy of Low- and High-Dose Iodine-131 for the Ablation of Thyroid Remnant
| Autor: | Hui Wang, Zhiyi Ye, Chao Ma, Hongliang Fu, Shaoyan Wang, Fang Feng, Shuqi Wu, Suyun Chen |
|---|---|
| Rok vydání: | 2017 |
| Předmět: |
Adult
Male China medicine.medical_specialty Neoplasm Residual Adolescent Endocrinology Diabetes and Metabolism medicine.medical_treatment Thyroid Gland chemistry.chemical_element Remnant ablation Iodine Thyroglobulin 030218 nuclear medicine & medical imaging Iodine Radioisotopes Thyroid carcinoma Young Adult 03 medical and health sciences 0302 clinical medicine Endocrinology Asian People medicine Humans Prospective Studies Thyroid Neoplasms Stage (cooking) Prospective cohort study Aged Aged 80 and over business.industry Thyroid Thyroidectomy Middle Aged Ablation Carcinoma Papillary Treatment Outcome medicine.anatomical_structure chemistry Thyroid Cancer Papillary Lymphatic Metastasis 030220 oncology & carcinogenesis Female Radiology business Nuclear medicine |
| Zdroj: | Thyroid. 27:832-837 |
| ISSN: | 1557-9077 1050-7256 |
| Popis: | Chinese data on the efficacy of low- and high-dose radioiodine for thyroid remnant are still absent. The aim of the study was to investigate whether a low dose of radioiodine is as effective as a high dose for remnant ablation in Chinese patients.Patients presenting for radioiodine ablation in the authors' department were included. Inclusion criteria were aged ≥16 years, total or near-total thyroidectomy, tumor-node-metastasis (TNM) stage of pT1-3, any N stage, and M0. All patients were randomly allocated to either the high-dose group of 3700 MBq or the low-dose group of 1850 MBq for remnant ablation. The response to treatment was defined as successful or unsuccessful after a six- to nine-month interval. Ablation was considered to be successful if patients fulfilled the following criteria: no tracer uptake in the thyroid bed on diagnosis whole-body scanning and a negative level of serum thyroglobulin.There were 327 patients enrolled between January 2013 and December 2014. More than 95% had papillary thyroid cancer. Data could be analyzed for 278 cases (MIn Chinese patients with differentiated thyroid carcinoma, the low dose of 1850 MBq radioiodine activity is as effective as a high dose of 3700 MBq for thyroid remnant ablation. |
| Databáze: | OpenAIRE |
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