Neighboring Genes Show Correlated Evolution in Gene Expression
| Autor: | Avazeh T. Ghanbarian, Laurence D. Hurst |
|---|---|
| Jazyk: | angličtina |
| Rok vydání: | 2015 |
| Předmět: |
gene expression evolution
Male Primates Pair-rule gene Biology Methylation Statistics Nonparametric Evolution Molecular Histones 03 medical and health sciences Cytosine 0302 clinical medicine Cerebellum Gene expression Gene cluster Genetics Animals Humans Computer Simulation Molecular Biology Gene Ecology Evolution Behavior and Systematics Discoveries 030304 developmental biology Regulation of gene expression 0303 health sciences Lysine sex-biased evolution gene clustering Chromatin Up-Regulation Nested gene Histone Gene Expression Regulation Genes Organ Specificity Chromosomes Human Pair 2 biology.protein 5-Methylcytosine Female Monte Carlo Method 030217 neurology & neurosurgery |
| Zdroj: | Molecular Biology and Evolution |
| ISSN: | 1537-1719 0737-4038 |
| Popis: | When considering the evolution of a gene’s expression profile, we commonly assume that this is unaffected by its genomic neighborhood. This is, however, in contrast to what we know about the lack of autonomy between neighboring genes in gene expression profiles in extant taxa. Indeed, in all eukaryotic genomes genes of similar expression-profile tend to cluster, reflecting chromatin level dynamics. Does it follow that if a gene increases expression in a particular lineage then the genomic neighbors will also increase in their expression or is gene expression evolution autonomous? To address this here we consider evolution of human gene expression since the human-chimp common ancestor, allowing for both variation in estimation of current expression level and error in Bayesian estimation of the ancestral state. We find that in all tissues and both sexes, the change in gene expression of a focal gene on average predicts the change in gene expression of neighbors. The effect is highly pronounced in the immediate vicinity ( |
| Databáze: | OpenAIRE |
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