Biological monitoring of environmental exposure to PAHs in the vicinity of a Soderberg aluminium reduction plant
| Autor: | C Viau, N L Gilbert |
|---|---|
| Rok vydání: | 1997 |
| Předmět: |
Adult
Male Non occupational Pilot Projects Urine High-performance liquid chromatography Excretion chemistry.chemical_compound Animal science Humans Polycyclic Compounds Chromatography High Pressure Liquid Creatinine Pyrenes Chemistry Quebec Public Health Environmental and Occupational Health Environmental exposure Middle Aged Industrial town Metallurgical industry Case-Control Studies Epidemiological Monitoring Metallurgy Female Biomarkers Research Article Aluminum Environmental Monitoring |
| Zdroj: | Occupational and Environmental Medicine. 54:619-621 |
| ISSN: | 1351-0711 |
| DOI: | 10.1136/oem.54.8.619 |
| Popis: | OBJECTIVES: To assess environmental exposure to polycyclic aromatic hydrocarbons (PAHs) in the vicinity of a Söderberg aluminium reduction plant in Shawinigan, Canada with urinary 1-hydroxypyrene (1-OHP) as a biomarker. METHODS: Urine samples were collected from 20 non-occupationally exposed subjects living less than 500 m from the plant and from 20 controls living in Trois-Rivières, another industrial town 40 km from Shawinigan. Concentrations of 1-OHP were measured by high performance liquid chromatography (HPLC). RESULTS: Among controls, geometric mean (range) 1-OHP concentrations were 0.046 (0.012-0.116) mumol/mol creatinine in non-smokers and 0.125 (0.051-0.282) mumol/mol creatinine in smokers. Among exposed subjects, values were 0.103 (0.056-0.196) mumol/mol creatinine in non-smokers and 0.250 (0.112-0.448) mumol/mol creatinine in smokers. Excretion of 1-OHP was significantly higher in exposed subjects than in controls among non-smokers and smokers (P < 0.05). CONCLUSION: Based on urinary 1-OHP as a biomarker, it seems that living near an industrial point source of PAHs is associated with higher exposure. The health significance of this finding will require further investigation. |
| Databáze: | OpenAIRE |
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