Effect of Osteoplasty with Bioactive Glass (S53P4) in Bone Healing - In vivo Experiment on Common European Rabbits (Oryctolagus cuniculus)
| Autor: | Ecaterina Matei, Solyom Arpad, Cristian Trambitas, Fodor Pal, Stefan Ioan Voicu, Eugeniu Vasile, Raluca Fodor, Tiberiu Bataga, Iulian Vasile Antoniac |
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| Rok vydání: | 2018 |
| Předmět: |
Osteoplasty
Pathology medicine.medical_specialty Bioactive glass S53P4 biology business.industry Materials Science (miscellaneous) Process Chemistry and Technology General Engineering General Chemistry General Medicine Bone healing General Biochemistry Genetics and Molecular Biology Materials Chemistry medicine biology.domesticated_animal In vivo experiment General Pharmacology Toxicology and Pharmaceutics European rabbit business |
| Zdroj: | Scopus-Elsevier |
| ISSN: | 2668-8212 0034-7752 |
| DOI: | 10.37358/rc.18.2.6121 |
| Popis: | Osteoplasty, is a procedure mostly applied in complicated bone fractures. Nowadays this method is widely used in primary fracture treatment while the native bone graft is progressively replaced with various synthetic bone substitutes. From the numerous bone grafts we�d like to mention a representative of ceramics, the S53P4 bioactive glass. (BonAlive�). The aim of this study was to investigate the healing process of different fracture types generated on rabbit femurs. During this experiment we used seven common European rabbits. We separated these animals into two groups; in the first group we surgically generated a total fracture in the middle 1/3 of the femur, while in the second group, we produced only a bone defect on the femur. The osteoplasty was carried out with bioactive glass and autologous bone grafts. The radiographic follow-up was immediate after the operation and after 3, 6 and 7 weeks. The animals were euthanized after 19, 20 and 21 weeks, for histomorphometric examination of the femur. It was also studied the ionic release from the used bioactive glass at physiological pH and the etching of the glass was studied by Scanning Electron Microscopy. |
| Databáze: | OpenAIRE |
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