Vaccine antigen production in transgenic plants: strategies, gene constructs and perspectives
| Autor: | Amanda Maree Walmsley, Stefano Castiglione, Barbara Basso, Maria Manuela Rigano, Francesco Sala, Alessandra Barbante |
|---|---|
| Přispěvatelé: | Sala, F., Rigano, MARIA MANUELA, Barbante, A., Basso, B., Walmsley, A. M., Castiglione, S. |
| Rok vydání: | 2003 |
| Předmět: |
Genetic Vectors
Administration Oral Genetically modified crops Biology Genome Antigen Immunity Plant virus Animals Antigens Immunity Mucosal Gene Expression vector General Veterinary General Immunology and Microbiology business.industry fungi Public Health Environmental and Occupational Health food and beverages Plants Genetically Modified Bioterrorism Virology Biotechnology Vaccination Infectious Diseases Public Opinion Antibody Formation Vaccines Subunit Molecular Medicine business |
| Zdroj: | Vaccine. 21:803-808 |
| ISSN: | 0264-410X |
| DOI: | 10.1016/s0264-410x(02)00603-5 |
| Popis: | Stable integration of a gene into the plant nuclear or chloroplast genome can transform higher plants (e.g. tobacco, potato, tomato, banana) into bioreactors for the production of subunit vaccines for oral or parental administration. This can also be achieved by using recombinant plant viruses as transient expression vectors in infected plants. The use of plant-derived vaccines may overcome some of the major problems encountered with traditional vaccination against infectious diseases, autoimmune diseases and tumours. They also offer a convenient tool against the threat of bio-terrorism. State of the art, experimental strategies, safety and perspectives are discussed in this article. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
|
Full Text from ScienceDirect