High prevalence of human papillomavirus infection in HIV-infected women living in French Antilles and French Guiana

Autor: Raymond Césaire, Akua Codjo-Sodokine, Fatiha Najioullah, Jean-Luc Voluménie, C Clavel, Déborah Chiappetta, Sylvie Abel, S. Stegmann-Planchard, Mathieu Nacher, Vincent Vantilcke, Dominique Catherine, Vincent Molinié, Laetitia Accrombessi, Gabriel Carles, Sandrine Pierre-François, Tania Vaz, Myriam El Guedj, André Cabié, Janick Jean-Marie
Jazyk: angličtina
Rok vydání: 2019
Předmět:
RNA viruses
Viral Diseases
European People
Cross-sectional study
HIV Infections
Pathology and Laboratory Medicine
Cervical Cancer
0302 clinical medicine
Immunodeficiency Viruses
Genotype
Medicine and Health Sciences
Prevalence
Ethnicities
Public and Occupational Health
French People
030212 general & internal medicine
Guadeloupe
Papillomaviridae
Cervical cancer
education.field_of_study
Multidisciplinary
HPV infection
virus diseases
HIV diagnosis and management
Middle Aged
Vaccination and Immunization
female genital diseases and pregnancy complications
French Guiana
Infectious Diseases
Oncology
Anti-Retroviral Agents
Medical Microbiology
Viral Pathogens
030220 oncology & carcinogenesis
Viruses
RNA
Viral
Medicine
Female
Pathogens
Research Article
Adult
Human Papillomavirus Infection
medicine.medical_specialty
Papillomaviruses
Alcohol Drinking
Urology
Science
Immunology
Population
Sexually Transmitted Diseases
Antiretroviral Therapy
Lower risk
Microbiology
03 medical and health sciences
Antiviral Therapy
Internal medicine
Retroviruses
medicine
Humans
Human papillomavirus
education
Microbial Pathogens
Genitourinary Infections
business.industry
Public health
Lentivirus
Papillomavirus Infections
Organisms
Biology and Life Sciences
HIV
Human Papillomavirus
Cancers and Neoplasms
medicine.disease
Diagnostic medicine
Cross-Sectional Studies
People and Places
HIV-1
Population Groupings
Preventive Medicine
DNA viruses
business
Gynecological Tumors
Zdroj: PLoS ONE, Vol 14, Iss 9, p e0221334 (2019)
PLoS ONE
ISSN: 1932-6203
Popis: An association between HIV infection and cervical cancer, a major public health issue worldwide, has been reported. The aim of this study was to estimate the prevalence of human papillomavirus (HPV) infection and the distribution of HPV genotypes in HIV-infected women living in French Antilles and Guiana and to determine HIV-related characteristics associated with HPV infection. This cross-sectional study included 439 HIV-infected women who were followed between January 2011 and May 2014. Variables related to HIV infections were collected, and cervical samples were analysed to determine HPV genotypes. The median age of the population was 46 years. Estimated prevalence of HPV and high-risk (HR)-HPV infection were 50.1% IC95 [45.4-54.7] and 42% IC95 [37.3-46.6], respectively. HR-HPV 16, 52, 53 or intermediate risk-HPV-68 were found in 25% to 30% of the HPV-infected patients. Gynaecological screening revealed abnormal cervical smear in 24% and 42% of HR-HPV-negative and HPV-positive women, respectively (p = 0.003). Approximately 90% of women were on antiretroviral therapy (ART). Demographic characteristics associated with a higher prevalence of HPV infection included alcohol consumption. Regarding HIV-related characteristics, current therapy on ART, its duration, and undetectable plasma concentrations of RNA-HIV1 were associated with a lower risk of HPV infection. Infection rate with HR-HPV was higher than what is commonly reported in HIV-negative women worldwide and was more likely in women with incomplete HIV suppression. These results highlight the need for supporting adherence to ART, cervical cytology, HPV testing and HPV vaccination.
Databáze: OpenAIRE
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