Continued neurogenesis is not a pre-requisite for regeneration of a topographic retino-tectal projection
| Autor: | Alison M. Harman, R. Beaver, J.D. Roberts, R.V. Stirling, Sarah A. Dunlop, Stephen S. Easter, Lyn Beazley |
|---|---|
| Rok vydání: | 2001 |
| Předmět: |
Aging
Optic nerve Central nervous system Xenopus Amphibia Xenopus laevis medicine Animals Regeneration Cilia Retina biology Regeneration (biology) Neurogenesis Cell generation Axotomy Retinotopy biology.organism_classification Sensory Systems Nerve Regeneration Electrophysiology Ophthalmology medicine.anatomical_structure Autoradiography Neuroscience Cell Division |
| Zdroj: | Vision Research. 41:1765-1770 |
| ISSN: | 0042-6989 |
| DOI: | 10.1016/s0042-6989(01)00053-0 |
| Popis: | Electrophysiological recording demonstrated that visuo-tectal projections are topographically organised after optic nerve regeneration in aged Xenopus laevis. 3H-thymidine autoradiography confirmed previous reports [Taylor, Lack, & Easter, Eur. Journal of Neuroscience 1 (1989) 626–638] that cell division had already ceased at the retinal ciliary margin. The results demonstrate that, contrary to a previous suggestion [Holder & Clarke, Trends in Neuroscience 11 (1988) 94–99], continued neurogenesis is not a pre-requisite for the re-establishment of appropriate connections with target cells. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
|
Full Text from ScienceDirect