Does the application of diffusion weighted imaging improve the prediction of survival in patients with resected brain metastases? A retrospective multicenter study
| Autor: | Matthias Preusser, David M Hughes, Suyash Mohan, Sanjeev Chawla, Yin Jie Chen, Anna S. Berghoff, Sumei Wang, Michael D. Jenkinson, Harish Poptani, Rasheed Zakaria |
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| Jazyk: | angličtina |
| Rok vydání: | 2020 |
| Předmět: |
lcsh:Medical physics. Medical radiology. Nuclear medicine
Adult Male medicine.medical_specialty medicine.medical_treatment Concordance lcsh:R895-920 DWI lcsh:RC254-282 030218 nuclear medicine & medical imaging Diffusion MRI 03 medical and health sciences 0302 clinical medicine Predictive Value of Tests medicine Effective diffusion coefficient Humans Radiology Nuclear Medicine and imaging Neoplasm Metastasis Aged Aged 80 and over Chemotherapy Univariate analysis Radiological and Ultrasound Technology Performance status business.industry Brain Neoplasms Brain metastasis General Medicine Middle Aged medicine.disease lcsh:Neoplasms. Tumors. Oncology. Including cancer and carcinogens Survival modelling Survival Analysis Diffusion Magnetic Resonance Imaging Oncology 030220 oncology & carcinogenesis Cohort Cerebral metastasis Female Personalised medicine Radiology business Biomarkers Research Article |
| Zdroj: | CANCER IMAGING Cancer Imaging Cancer Imaging, Vol 20, Iss 1, Pp 1-7 (2020) |
| Popis: | Background Brain metastases are common in clinical practice. Many clinical scales exist for predicting survival and hence deciding on best treatment but none are individualised and none use quantitative imaging parameters. A multicenter study was carried out to evaluate the prognostic utility of a simple diffusion weighted MRI parameter, tumor apparent diffusion coefficient (ADC). Methods A retrospective analysis of imaging and clinical data was performed on a cohort of 223 adult patients over a ten-year period 2002–2012 pooled from three institutions. All patients underwent surgical resection with histologically confirmed brain metastases and received adjuvant whole brain radiotherapy and/or chemotherapy. Survival was modelled using standard clinical variables and statistically compared with and without the addition of tumor ADC. Results The median overall survival was 9.6 months (95% CI 7.5–11.7) for this cohort. Greater age (p = 0.002), worse performance status (p p p = 0.007) and higher tumor ADC (p Conclusions Combining advanced MRI readings such as tumor ADC with clinical scoring systems is a potentially simple method for improving and individualising the estimation of survival in patients having surgery for brain metastases. |
| Databáze: | OpenAIRE |
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