SYMMETRICAL FEATURES IN POLYPEPTIDE HORMONE-RECEPTOR INTERACTIONS
| Autor: | K. Sasaki, S. Dockerill, Dr.C.R. Beddell, G.C. Sheppey, P.J. Goodford, Tom L. Blundell |
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| Rok vydání: | 2009 |
| Předmět: |
Symmetry element
chemistry.chemical_classification Binding Sites Protein Conformation Chemistry Stereochemistry Angiotensin II Molecular Conformation Receptors Cell Surface Biological activity Peptide Peptide hormone Bradykinin Glucagon Biochemistry Amino acid Gonadotropin-Releasing Hormone Amino Acid Sequence Approximate symmetry Binding site Peptides Receptor Thyrotropin-Releasing Hormone |
| Zdroj: | International Journal of Peptide and Protein Research. 9:161-165 |
| ISSN: | 0367-8377 |
| Popis: | Symmetrical features were observed in the amino acid sequences of some biologically active peptides. It is suggested that this approximate symmetry is reflected in the conformations of the peptides at their respective biological receptors, and has arisen by natural selection as both peptides and receptors evolved to optimise their mutual fit. It follows that the binding site for each peptide at its receptor would share the same symmetry element. This would arise if the peptide binds to two symmetrically related similar or identical submits in the receptor. |
| Databáze: | OpenAIRE |
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