Tuberculosis Drug Discovery: Challenges and New Horizons

Autor:	Guilherme F. S. Fernandes, Andrew M. Thompson, Daniele Castagnolo, William A. Denny, Jean L. Dos Santos
Rok vydání:	2022
Předmět:	Drug Discovery Antitubercular Agents Humans Tuberculosis Molecular Medicine Mycobacterium tuberculosis COVID-19 Drug Treatment
Zdroj:	Journal of Medicinal Chemistry. 65:7489-7531
ISSN:	1520-4804 0022-2623
DOI:	10.1021/acs.jmedchem.2c00227
Popis:	Over the past 2000 years, tuberculosis (TB) has claimed more lives than any other infectious disease. In 2020 alone, TB was responsible for 1.5 million deaths worldwide, comparable to the 1.8 million deaths caused by COVID-19. The World Health Organization has stated that new TB drugs must be developed to end this pandemic. After decades of neglect in this field, a renaissance era of TB drug discovery has arrived, in which many novel candidates have entered clinical trials. However, while hundreds of molecules are reported annually as promising anti-TB agents, very few successfully progress to clinical development. In this Perspective, we critically review those anti-TB compounds published in the last 6 years that demonstrate good
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f64e0d2dcb30d085870dd97619a1089b https://doi.org/10.1021/acs.jmedchem.2c00227 Zobrazit plný text záznamu