Sequence comparison of human and murine erythrocyte alpha-spectrin cDNA
| Autor: | Sara Shane, Antonio Palumbo, Livia Cioe, Pacifico Meo, Peter Fraser, Giovanni Rovera, Peter J. Curtis, Jeffrey Ming |
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| Předmět: |
macromolecular substances
Molecular cloning Biology Mice chemistry.chemical_compound Sequence Homology Nucleic Acid Complementary DNA Genetics Animals Humans Spectrin RNA Messenger Cloning Molecular Repeated sequence Gene Repetitive Sequences Nucleic Acid chemistry.chemical_classification Protein primary structure DNA DNA Restriction Enzymes General Medicine Molecular biology Amino acid Genes chemistry |
| Zdroj: | Scopus-Elsevier |
| Popis: | The results of hybridization analyses using cDNA probes for mouse and human alpha-spectrin mRNA indicate that a single gene encodes the alpha-subunit of erythrocyte spectrin. Sequencing of the cDNA clones showed that they code for 370 amino acids (aa) covering three repeat domains close to the C terminus of alpha-spectrin. The cloned cDNAs will now permit the isolation of the alpha-spectrin gene and should lead to the characterization of the genetic aspects in human hereditary anemias in which alpha-spectrin has been characterized as the site of the molecular defect. |
| Databáze: | OpenAIRE |
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