Effect of second-generation antipsychotics on brain network topology in first-episode schizophrenia: A longitudinal rs-fMRI study
| Autor: | Long-Biao Cui, Yi-Bin Xi, Yuanqiang Zhu, Xing-Rui Wang, Liu-Xian Wang, Chen Li, Huaning Wang, Fan Guo, Wen-Ming Liu, Hong Yin |
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| Rok vydání: | 2019 |
| Předmět: |
Adult
Male Adolescent Rest medicine.medical_treatment Topology Young Adult 03 medical and health sciences 0302 clinical medicine Neural Pathways Image Processing Computer-Assisted medicine Humans Longitudinal Studies Antipsychotic Biological Psychiatry First episode medicine.diagnostic_test Functional integration (neurobiology) business.industry Brain Magnetic resonance imaging Middle Aged medicine.disease Magnetic Resonance Imaging 030227 psychiatry Psychiatry and Mental health Treatment Outcome Schizophrenia Connectome Biomarker (medicine) Female Functional magnetic resonance imaging business 030217 neurology & neurosurgery Antipsychotic Agents Follow-Up Studies |
| Zdroj: | Schizophrenia Research. 208:160-166 |
| ISSN: | 0920-9964 |
| DOI: | 10.1016/j.schres.2019.03.015 |
| Popis: | Objective We aimed to evaluate the functional network properties in first-episode schizophrenia (SZ) patients at baseline and after 4-months treatment with second-generation antipsychotic drugs. Methods Resting-state functional magnetic resonance imaging and graph theory approaches were utilized to evaluate the functional integration and segregation of brain networks in 36 first-episode patients (20 male/16 female) with SZ and 36 age and sex matched healthy controls (20 male/16 female). Results Compared with healthy controls, SZ at baseline showed lower clustering coefficient (Cp) and local network efficiency (Eloc), and this abnormal pattern was modulated with treatment of antipsychotic drugs at follow-up. Longitudinally, the increase of Cp was associated with the improvement of negative symptom. We found that the strength of functional connectivity between brain regions were significantly increased in three connections after treatment, mainly involving the frontal, parietal and occipital lobes. Conclusion The current study suggested that antipsychotic drugs could modulate the faulty local clustering of the functional connectome in SZ. Furthermore, Cp, the parameter that reflects local clustering of topological organization, demonstrated the potential to be a connectome-based biomarker of treatment response to second-generation antipsychotics in patients with SZ. |
| Databáze: | OpenAIRE |
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