Undernutrition during pregnancy in mice leads to dysfunctional cardiac muscle respiration in adult offspring
| Autor: | Nathan McIntosh, A. Brianne Thrush, Mary-Elizabeth Patti, Mary-Ellen Harper, Ghadi Antoun, Brittany Beauchamp, Jessica K. Quizi, Osama Y. Al-Dirbashi |
|---|---|
| Rok vydání: | 2015 |
| Předmět: |
medicine.medical_specialty
obesity medicine.medical_treatment Biophysics Intrauterine growth restriction Mitochondrion Biochemistry Mitochondria Heart Insulin resistance Pregnancy Internal medicine Carnitine Respiration medicine Animals Birth Weight Molecular Biology Prenatal Nutritional Physiological Phenomena reproductive and urinary physiology 2. Zero hunger energetics Mice Inbred ICR Original Paper business.industry Insulin Myocardium Malnutrition Cardiac muscle Heart Cell Biology medicine.disease Original Papers 3. Good health mitochondria Endocrinology medicine.anatomical_structure fetal programming Liver In utero Female business Energy Metabolism metabolism |
| Zdroj: | Bioscience Reports |
| ISSN: | 1573-4935 |
| Popis: | We show that in utero undernutrition is associated with impaired cardiac muscle energetics and increased plasma short-chain acylcarnitines in adult mice. Findings suggest that in utero undernutrition is associated with maladaptive programming processes that have negative effects on the heart. Intrauterine growth restriction (IUGR) is associated with an increased risk of developing obesity, insulin resistance and cardiovascular disease. However, its effect on energetics in heart remains unknown. In the present study, we examined respiration in cardiac muscle and liver from adult mice that were undernourished in utero. We report that in utero undernutrition is associated with impaired cardiac muscle energetics, including decreased fatty acid oxidative capacity, decreased maximum oxidative phosphorylation rate and decreased proton leak respiration. No differences in oxidative characteristics were detected in liver. We also measured plasma acylcarnitine levels and found that short-chain acylcarnitines are increased with in utero undernutrition. Results reveal the negative impact of suboptimal maternal nutrition on adult offspring cardiac energy metabolism, which may have life-long implications for cardiovascular function and disease risk. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
|