Effect of mandibular advancement device treatment on HIF-1α, EPO and VEGF in the myocardium of obstructive sleep apnea–hypopnea syndrome rabbits
Autor: | Dechao Zhu, Shilong Zhang, Xing Qiao, Haiyan Lu, Wenjing Kang, Jie Liu, Chunyan Liu |
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Jazyk: | angličtina |
Rok vydání: | 2020 |
Předmět: |
0301 basic medicine
Male Vascular Endothelial Growth Factor A Supine position lcsh:Medicine Diseases Polysomnography Pathogenesis chemistry.chemical_compound 0302 clinical medicine Signs and symptoms lcsh:Science Sleep Apnea Obstructive Multidisciplinary medicine.diagnostic_test Sleep apnea Occlusal Splints Cone-Beam Computed Tomography Up-Regulation Vascular endothelial growth factor Cardiology Rabbits Anatomy Hypopnea medicine.drug medicine.medical_specialty animal structures Article 03 medical and health sciences Internal medicine medicine Animals Erythropoietin business.industry Myocardium lcsh:R medicine.disease Hypoxia-Inducible Factor 1 alpha Subunit Obstructive sleep apnea Disease Models Animal 030104 developmental biology chemistry Risk factors Case-Control Studies lcsh:Q business Airway 030217 neurology & neurosurgery Biomarkers |
Zdroj: | Scientific Reports, Vol 10, Iss 1, Pp 1-10 (2020) Scientific Reports |
ISSN: | 2045-2322 |
Popis: | The aim of this study was to investigate the effects of mandibular advancement device (MAD) therapy for obstructive sleep apnea–hypopnea syndrome (OSAHS) on hypoxia-inducible factor-1α (HIF-1α), erythropoietin (EPO) and vascular endothelial growth factor (VEGF) in myocardial tissue. New Zealand rabbits were used to develop OSAHS and MAD models. Cone beam computed tomography (CBCT) of the upper airway and polysomnography (PSG) recordings were performed with the animals in the supine position. All of the animals were induced to sleep in a supine position for 4–6 h each day and were observed continuously for 8 weeks. The myocardial tissue of the three groups was dissected to measure the expression of HIF-1α, EPO and VEGF. The results showed that there was higher expression of HIF-1α, EPO and VEGF in the OSAHS group than those in the MAD and control groups. MAD treatment significantly downregulated the expression of HIF-1α, EPO and VEGF in the OSAHS animals. We concluded that MAD treatment could significantly downregulate the increased expression of HIF-1α, EPO and VEGF in OSAHS rabbits, improving their myocardial function. |
Databáze: | OpenAIRE |
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