Effect of mandibular advancement device treatment on HIF-1α, EPO and VEGF in the myocardium of obstructive sleep apnea–hypopnea syndrome rabbits

Autor: Dechao Zhu, Shilong Zhang, Xing Qiao, Haiyan Lu, Wenjing Kang, Jie Liu, Chunyan Liu
Jazyk: angličtina
Rok vydání: 2020
Předmět:
0301 basic medicine
Male
Vascular Endothelial Growth Factor A
Supine position
lcsh:Medicine
Diseases
Polysomnography
Pathogenesis
chemistry.chemical_compound
0302 clinical medicine
Signs and symptoms
lcsh:Science
Sleep Apnea
Obstructive
Multidisciplinary
medicine.diagnostic_test
Sleep apnea
Occlusal Splints
Cone-Beam Computed Tomography
Up-Regulation
Vascular endothelial growth factor
Cardiology
Rabbits
Anatomy
Hypopnea
medicine.drug
medicine.medical_specialty
animal structures
Article
03 medical and health sciences
Internal medicine
medicine
Animals
Erythropoietin
business.industry
Myocardium
lcsh:R
medicine.disease
Hypoxia-Inducible Factor 1
alpha Subunit
Obstructive sleep apnea
Disease Models
Animal
030104 developmental biology
chemistry
Risk factors
Case-Control Studies
lcsh:Q
business
Airway
030217 neurology & neurosurgery
Biomarkers
Zdroj: Scientific Reports, Vol 10, Iss 1, Pp 1-10 (2020)
Scientific Reports
ISSN: 2045-2322
Popis: The aim of this study was to investigate the effects of mandibular advancement device (MAD) therapy for obstructive sleep apnea–hypopnea syndrome (OSAHS) on hypoxia-inducible factor-1α (HIF-1α), erythropoietin (EPO) and vascular endothelial growth factor (VEGF) in myocardial tissue. New Zealand rabbits were used to develop OSAHS and MAD models. Cone beam computed tomography (CBCT) of the upper airway and polysomnography (PSG) recordings were performed with the animals in the supine position. All of the animals were induced to sleep in a supine position for 4–6 h each day and were observed continuously for 8 weeks. The myocardial tissue of the three groups was dissected to measure the expression of HIF-1α, EPO and VEGF. The results showed that there was higher expression of HIF-1α, EPO and VEGF in the OSAHS group than those in the MAD and control groups. MAD treatment significantly downregulated the expression of HIF-1α, EPO and VEGF in the OSAHS animals. We concluded that MAD treatment could significantly downregulate the increased expression of HIF-1α, EPO and VEGF in OSAHS rabbits, improving their myocardial function.
Databáze: OpenAIRE
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