The Complex Relationship between HTLV-1 and Nonsense-Mediated mRNA Decay (NMD)
| Autor: | Pierre Jalinot, Vincent Mocquet, Léa Prochasson |
|---|---|
| Přispěvatelé: | Laboratoire de biologie et modélisation de la cellule (LBMC UMR 5239), École normale supérieure - Lyon (ENS Lyon)-Université Claude Bernard Lyon 1 (UCBL), Université de Lyon-Université de Lyon-Institut National de la Santé et de la Recherche Médicale (INSERM)-Centre National de la Recherche Scientifique (CNRS), École normale supérieure de Lyon (ENS de Lyon)-Université Claude Bernard Lyon 1 (UCBL), MOCQUET, VINCENT |
| Jazyk: | angličtina |
| Rok vydání: | 2020 |
| Předmět: |
Microbiology (medical)
Intrinsic immunity nonsense mRNA Decay Nonsense-mediated decay lcsh:Medicine Review Biology [SDV.IMM.II]Life Sciences [q-bio]/Immunology/Innate immunity 03 medical and health sciences 0302 clinical medicine Retrovirus antiviral process Immunology and Allergy [SDV.IMM.II] Life Sciences [q-bio]/Immunology/Innate immunity Molecular Biology 030304 developmental biology Ribonucleoprotein [SDV.MP.VIR] Life Sciences [q-bio]/Microbiology and Parasitology/Virology 0303 health sciences Messenger RNA General Immunology and Microbiology lcsh:R RNA biology.organism_classification RNA Helicase A Cell biology retrovirus Infectious Diseases Viral replication HTLV-1 UPF1 [SDV.MP.VIR]Life Sciences [q-bio]/Microbiology and Parasitology/Virology 030217 neurology & neurosurgery |
| Zdroj: | Pathogens Pathogens, MDPI, 2020, 9 (4), pp.287. ⟨10.3390/pathogens9040287⟩ Pathogens, Vol 9, Iss 287, p 287 (2020) Pathogens, 2020, 9 (4), pp.287. ⟨10.3390/pathogens9040287⟩ |
| ISSN: | 2076-0817 |
| DOI: | 10.3390/pathogens9040287⟩ |
| Popis: | International audience; Before the establishment of an adaptive immune response, retroviruses can be targeted by several cellular host factors at different stages of the viral replication cycle. This intrinsic immunity relies on a large diversity of antiviral processes. In the case of HTLV-1 infection, these active innate host defense mechanisms are debated. Among these mechanisms, we focused on an RNA decay pathway called nonsense-mediated mRNA decay (NMD), which can target multiple viral RNAs, including HTLV-1 unspliced RNA, as has been recently demonstrated. NMD is a co-translational process that depends on the RNA helicase UPF1 and regulates the expression of multiple types of host mRNAs. RNA sensitivity to NMD depends on mRNA organization and the ribonucleoprotein (mRNP) composition. HTLV-1 has evolved several means to evade the NMD threat, leading to NMD inhibition. In the early steps of infection, NMD inhibition favours the production of HTLV-1 infectious particles, which may contribute to the survival of the fittest clones despite genome instability; however, its direct long-term impact remains to be investigated. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
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