Role of Lactobacillus Species in the Intermediate Vaginal Flora in Early Pregnancy: A Retrospective Cohort Study
| Autor: | Verena Kueronya, Peter Husslein, Iris Holzer, Ljubomir Petricevic, Susanne Machal, Michael Hagmann, Herbert Kiss, Alex Farr |
|---|---|
| Rok vydání: | 2015 |
| Předmět: |
medicine.medical_specialty
lcsh:Medicine Gestational Age Obstetrics and gynaecology Pregnancy Lactobacillus medicine Birth Weight Humans lcsh:Science Retrospective Studies Vaginal Smears Gynecology Multidisciplinary biology business.industry Obstetrics Vaginal flora lcsh:R Gestational age Retrospective cohort study Delivery Obstetric medicine.disease biology.organism_classification medicine.anatomical_structure Multivariate Analysis Vagina Female lcsh:Q Bacterial vaginosis business Research Article Follow-Up Studies |
| Zdroj: | PLoS ONE, Vol 10, Iss 12, p e0144181 (2015) PLoS ONE |
| ISSN: | 1932-6203 |
| Popis: | Background Poor obstetrical outcomes are associated with imbalances in the vaginal flora. The present study evaluated the role of vaginal Lactobacillus species in women with intermediate vaginal flora with regard to obstetrical outcomes. Methods We retrospectively analysed data from all women with singleton pregnancies who had undergone routine screening for asymptomatic vaginal infections at our tertiary referral centre between 2005 and 2014. Vaginal smears were Gram-stained and classified according to the Nugent scoring system as normal flora (score 0–3), intermediate vaginal flora (4–6), or bacterial vaginosis (7–10). Only women with intermediate vaginal flora were investigated. Women with a Nugent score of 4 were categorised into those with and without Lactobacilli. Follow-up smears were obtained 4–6 weeks after the initial smears. Descriptive data analysis, the Welch’s t-test, the Fisher’s exact test, and multiple regression analysis with adjustment for confounders were performed. Gestational age at delivery and birth weight were the outcome measures. Results At antenatal screening, 529/8421 women presented with intermediate vaginal flora. Amongst these, 349/529 (66%) had a Nugent score of 4, 94/529 (17.8%) a Nugent score of 5, and 86/529 (16.2%) a Nugent score of 6. Amongst those with a Nugent score of 4, 232/349 (66.5%) women were in the Lactobacilli group and 117/349 (33.5%) in the Non-Lactobacilli group. The preterm delivery rate was significantly lower in the Lactobacilli than in the Non-Lactobacilli group (OR 0.34, CI 0.21–0.55; p |
| Databáze: | OpenAIRE |
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