Aspects of protein metabolism after elective surgery in patients receiving constant nutritional support
| Autor: | V. Ramachandra, Victor R. Preedy, M. Pearson, J. Webster, S. McArthur, D. Halliday, G.C. Ford, M Read, F. Carli |
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| Rok vydání: | 1990 |
| Předmět: |
Adult
Parenteral Nutrition medicine.medical_specialty Nitrogen medicine.medical_treatment Protein metabolism Muscle Proteins Biology Hysterectomy chemistry.chemical_compound Internal medicine medicine Humans Postoperative Period Elective surgery Insulin Protein turnover Proteins General Medicine Metabolism Middle Aged Methylhistidines Diet Respiratory quotient Glutamine Forearm Endocrinology chemistry Regional Blood Flow Basal metabolic rate Female |
| Zdroj: | Clinical Science. 78:621-628 |
| ISSN: | 1470-8736 0143-5221 |
| DOI: | 10.1042/cs0780621 |
| Popis: | 1. The present study was designed in an attempt to resolve conflicting views currently in the literature relating to the effect of surgery on various aspects of protein metabolism. 2. Sequential post-operative (2, 4 and 6 days) changes in whole-body protein turnover, forearm arteriovenous difference of plasma amino acids, glucose, lactate and free fatty acids, muscle concentration of free amino acids, RNA and protein, urinary nitrogen and 3-methylhistidine, plasma concentrations of insulin, cortisol and growth hormone, and resting metabolic rate, were measured in six patients undergoing uncomplicated elective total abdominal hysterectomy. 3. All patients received a constant daily diet, either orally or intravenously, based on 0.1 g of nitrogen/kg and an energy content of 1.1 times the resting metabolic rate for 7 days before and 6 days after surgery. 4. Whole-body protein turnover, synthesis and breakdown increased significantly 2 days after surgery (P 5. Forearm release of branched-chain amino acids and alanine, and efflux of glucose and lactate, were enhanced 4 days after surgery (P 6. A significant increase in urinary nitrogen and 3-methylhistidine was observed on days 3 and 4 after surgery (P 7. The resting metabolic rate was significantly increased (P 8. These data support the contention that whole-body protein synthesis and breakdown increase after surgery. Differences observed pre- and post-operatively between leucine kinetic estimates and other methods of quantifying protein metabolism indicate that only like methodologies should be compared. |
| Databáze: | OpenAIRE |
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